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ARENEDICARBOXIMIDES AS DUAL FLUORESCENT MOLECULAR PROBES

Award Number: R15GM057855
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 09/01/1998
PERIOD OF PERFORMANCE END DATE: 03/31/2009

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ARENEDICARBOXIMIDES AS DUAL FLUORESCENT MOLECULAR PROBES - DESCRIPTION (provided by applicant): In aim 1, a 3 x 7 synthetic matrix of substituted N-phenyl-arenecarboximides will be used for screening and identifying dual fluorescent dyes. The proposed matrix elements are based on preliminary findings which indicate optimum substituent placement on arene components to promote the unique dual fluorescent phenomena. To demonstrate the versatility of these 2-color systems, functional groups for various ionic and neutral analytes are briefly outlined. Aim 2 of the application involves the use of the "Internal Stark Effect" as a minimal modification approach to extending the absorption and emission wavelengths of these fluorescent probes. Their electrochromic behavior would allow for direct application as fluorescent probes for measuring micropolarity in surfaces of natural and synthetic macromolecules, micelles, phospholipid bilayers, and biomembranes. Aim 3 projections for this work include the development of arenedicarboximides as fluorescent proteomimetics for potential use in mediating protein-protein interactions. These probes would allow for direct optical measurement of helix surface recognition and therefore providing binding information along targeted sites of the protein.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $256,273 )
2006	2006	NEW MEXICO INSTITUTE OF MINING & TECHNOLOGY	801 LEROY AVENUE	SOCORRO	NM	87801	SOCORRO	USA	Biomedical Research and Research Training	001	3	7/24/2006	SUPPLEMENT FOR EXPANSION	$35,623
2006	2006	NEW MEXICO INSTITUTE OF MINING & TECHNOLOGY	801 LEROY AVENUE	SOCORRO	NM	87801	SOCORRO	USA	Biomedical Research and Research Training	000	3	3/30/2006	COMPETING CONTINUATION	$220,650
														Subtotal = $256,273

Issue Date FY: 2005 ( Subtotal = $11,018 )
2005	2005	NEW MEXICO INSTITUTE OF MINING & TECHNOLOGY	801 LEROY AVENUE	SOCORRO	NM	87801	SOCORRO	USA	Biomedical Research and Research Training	002	2	6/20/2005	SUPPLEMENT FOR EXPANSION	$11,018
														Subtotal = $11,018

Issue Date FY: 2003 ( Subtotal = $30,098 )
2003	2003	NEW MEXICO INSTITUTE OF MINING & TECHNOLOGY	801 LEROY AVENUE	SOCORRO	NM	87801	SOCORRO	USA	Biomedical Research and Research Training	001	2	7/17/2003	SUPPLEMENT FOR EXPANSION	$30,098
														Subtotal = $30,098

Issue Date FY: 2002 ( Subtotal = $137,995 )
2002	2002	NEW MEXICO INSTITUTE OF MINING & TECHNOLOGY	801 LEROY AVENUE	SOCORRO	NM	87802		USA	Academic Research Enhancement Award	000	2	8/9/2002	COMPETING CONTINUATION	$137,995
														Subtotal = $137,995

Issue Date FY: 1998 ( Subtotal = $106,686 )
1998	1998	NEW MEXICO INSTITUTE OF MINING & TECHNOLOGY	**	SOCORRO	NM	87801	SOCORRO	USA	Biomedical Research and Research Training	000	1	8/24/1998	NEW	$106,686
														Subtotal = $106,686

Grand Total All Awards = $542,070

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ARENEDICARBOXIMIDES AS DUAL FLUORESCENT MOLECULAR PROBES

Award Number: R15GM057855

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 09/01/1998

PERIOD OF PERFORMANCE END DATE: 03/31/2009

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