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Effect of ambient heat on chronic kidney disease and end-stage kidney disease among US veterans

Award Number: R15ES035227
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Effect of ambient heat on chronic kidney disease and end-stage kidney disease among US veterans - Chronic kidney disease (CKD) is a major public health concern in the United States. An estimated 15 percent of U.S. adults, or about 37 million people, have CKD. Among potentially modifiable meteorological factors, exposure to high ambient heat has been associated with kidney-related outcomes in several populations. However, most existing evidence focuses on short periods of unusually high temperature and their short-term impacts, such as acute kidney injury or heat-related hospital visits. There is limited epidemiologic research on how sustained or non-extreme ambient heat influences the development of CKD, its progression to end-stage kidney disease (ESKD), or the biological pathways involved. This application aims to evaluate the relationship between ambient heat and new-onset CKD among adults with normal kidney function at baseline. It also aims to examine the association between ambient heat and progression to ESKD among individuals with incident CKD, as well as to explore potential physiological pathways related to hydration status and electrolyte balance. To accomplish this, we will link gridded meteorological variables from the Parameter Elevation Relationships on Independent Slopes Model (PRISM) dataset with longitudinal clinical and biomarker data from the Racial and Cardiovascular Risk Anomalies in CKD (RCAV) cohort of U.S. Veterans. We will use logistic regression models to estimate the associations between lagged ambient temperature and incident CKD, and between lagged ambient temperature and progression to ESKD. Causal mediation analyses will be used to assess whether biomarkers related to hydration and electrolyte abnormalities help explain these relationships. The proposed research will provide new evidence on the role of ambient heat in the development and progression of kidney disease. The findings may help inform future clinical and public health strategies aimed at preventing CKD or slowing disease progression in populations that experience high ambient temperatures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2023	UNIVERSITY OF MEMPHIS	115 JOHN WILDER TOWER	MEMPHIS	TN	38152	SHELBY	USA	Environmental Health	000	1	12/11/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $433,349 )
2023	2023	UNIVERSITY OF MEMPHIS, THE	101 WILDER TOWER	MEMPHIS	TN	38152	SHELBY	USA	Environmental Health	000	1	4/26/2023	NEW	$433,349
														Subtotal = $433,349

Grand Total All Awards = $433,349

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Effect of ambient heat on chronic kidney disease and end-stage kidney disease among US veterans

Award Number: R15ES035227

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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