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Mechanistic evaluation of chemicals that induce oral acute toxicity by novel read-across approaches using public big data

Award Number: R15ES023148
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT As one of the major potential alternatives to animal models, the read-across of toxicity data within groups of similar compounds represents a promising direction to fill the data gap in chemical safety assessment. While read-across can play a key role in complying with legislation (e.g. the European REACH regulation), most of the current read-across tools only rely on chemical structure information. With more and more available biological data, read-across based on big data can add extra strength to this process. In this project, we will develop an automated computational approach 1) to explore the public big data sources and generate the bioprofiles; 2) to perform a read- cross study using the target 10,000 compounds with animal acute toxicity data; and 3) to reveal the potential toxicity mechanisms from the public biological data. Then the external acute toxicity database, which contains around 5,000 new compounds, will be used to validate the resulting read-across approach. Moreover, we will share with the toxicology community the developed read-across tool via Chemical In vitro-In vivo Profiling (CIIPro) portal (ciipro.rutgers.edu), which has been proven to be a useful toxicity evaluation tool by US EPA. The toxicologists can use the CIIPro portal to directly evaluate acute toxicity of new compounds avoiding animal testing; to illustrate the relevant toxicity mechanisms; and to prioritize toxic compounds of environmental interest for future animal studies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$1,327 )
2023	2018	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	303 COOPER ST	CAMDEN	NJ	08102	CAMDEN	USA	Environmental Health	000	2	4/6/2023	COMPETING CONTINUATION	-$1,327
														Subtotal = -$1,327

Issue Date FY: 2018 ( Subtotal = $475,905 )
2018	2018	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	303 COOPER ST	CAMDEN	NJ	08102	CAMDEN	USA	Environmental Health	001	2	8/9/2018	COMPETING CONTINUATION	$475,905
2018	2013	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	303 COOPER ST	CAMDEN	NJ	08102	CAMDEN	USA	Environmental Health	000	1	12/5/2017	NEW	$0
														Subtotal = $475,905

Issue Date FY: 2013 ( Subtotal = $464,983 )
2013	2013	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLAZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Environmental Health	000	1	8/9/2013	NEW	$464,983
														Subtotal = $464,983

Grand Total All Awards = $939,561

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Mechanistic evaluation of chemicals that induce oral acute toxicity by novel read-across approaches using public big data

Award Number: R15ES023148

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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