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Biomimetic Triphasic Interference Screws for Bone-Ligament/Tendon Regeneration: A Synergistic Approach Combining Design, Manufacturing, and Biological Validation

Award Number: R15AR087120
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Biomimetic Triphasic Interference Screws for Bone-Ligament/Tendon Regeneration: A Synergistic Approach Combining Design, Manufacturing, and Biological Validation - Summary Statement: This R15 proposal aims to develop next-generation interference screws with biomimetic tissue-specific architectures to improve bone-ligament/tendon reconstruction outcomes. The clinical significance stems from the high failure rates (20-25%) of current anterior cruciate ligament (ACL) reconstructions within 7-10 years, with nearly half requiring second revision surgery. The project's innovation lies in creating the first-ever triphasic interference screws that actively facilitate simultaneous bone and ligament/tendon regeneration through tissue-mimetic gradient structures and zone-specific biochemical modifications. The research objectives will be accomplished through three specific aims: (1) Design and manufacture triphasic matrices with bone-mimetic and ligament-mimetic architectures using advanced ceramic/polymer 3D printing, (2) Investigate zone-specific bimetallic ion modification and tissue regeneration capabilities through in vitro studies, and (3) Develop and validate optimized interference screws through computational modeling and mechanical testing. This project will provide research training opportunities for biomedical and mechanical engineering undergraduate students. At least four undergraduate students per year will gain hands-on experience in computer-aided design, advanced manufacturing, cell culture techniques, and biomechanical testing. The research environment will foster student development through mentored experiences in 3D printing, materials characterization, bio design apparatus setup and computational analysis and biological assessment. Additionally, the project will establish partnerships with local high schools and community colleges to provide summer research experiences. All research training opportunities supported by this award will be open to interested students without regard to race, ethnicity, or sex, with participants selected on the basis of demonstrated interest in engineering, academic preparation, and readiness to contribute to the research. The expected outcomes include: (1) Novel biomimetic interference screws with validated tissue regeneration capabilities, (2) Fundamental understanding of how structural and biochemical gradients influence bone-ligament healing, and (3) Development of a skilled workforce in biomedical engineering through hands-on research training.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $573,354 )
2026	2026	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/1/2026	NEW	$573,354
														Subtotal = $573,354

Grand Total All Awards = $573,354

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Biomimetic Triphasic Interference Screws for Bone-Ligament/Tendon Regeneration: A Synergistic Approach Combining Design, Manufacturing, and Biological Validation

Award Number: R15AR087120

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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