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Developmental regulation of filamentation by the homeodomain transcription factor Grf10 of Candida albicans

Award Number: R15AI124160
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Candida albicans is an opportunistic fungal pathogen and the major cause of human fungal infections. It is a commensal organism that is found in the majority of immunocompetent individuals; however, it causes superficial mucosal infections and life-threatening systemic infections particularly in those who are immunocompromised. The morphology of this fungus changes from yeast to filamentous forms, and this dimorphic transition is linked to its virulence. The long-term goals of this project are to understand the molecular mechanisms of fungal pathogenesis. The immediate goals are to investigate the homeodomain transcription factor Grf10, which is important for cells to undergo the dimorphic transition, by investigating its co-regulators and regulated genes. Co-regulators will be identified using protein interaction assays and biochemical purification, and regulated genes will be investigated by examining RNA levels. The results of these experiments will increase our understanding of the molecular pathways necessary for filamentation of Candida albicans, an important fungal pathogen, and may provide new strategies for therapeutic targets.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $451,242 )
2023	2023	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Allergy and Infectious Diseases Research	001	2	11/18/2022	COMPETING CONTINUATION	$458,758
2023	2017	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Allergy and Infectious Diseases Research	000	1	10/1/2022	NEW	-$7,516
														Subtotal = $451,242

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2017	GEORGETOWN UNIVERSITY (THE)	37TH AND O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Allergy and Infectious Diseases Research	000	1	3/16/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $441,415 )
2017	2017	GEORGETOWN UNIVERSITY (THE)	37TH & O STS NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Allergy and Infectious Diseases Research	000	1	12/28/2016	NEW	$441,415
														Subtotal = $441,415

Grand Total All Awards = $892,657

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Developmental regulation of filamentation by the homeodomain transcription factor Grf10 of Candida albicans

Award Number: R15AI124160

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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