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Exploring mechanisms of aging in eukaryotes

Award Number: R15AG037158
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2011
PERIOD OF PERFORMANCE END DATE: 02/17/2014

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Exploring mechanisms of aging in eukaryotes - DESCRIPTION (provided by applicant): The long-term objective of this research is to better understand the biochemical, genetic and physiological mechanisms of aging and age related changes in man through investigation of similar biochemical and physiological changes in the domestic dog, Canis familiaris. With life span in the American population nearly doubling in the last century, it is becoming of greater importance both economically and socially, to understand the biological mechanisms allowing for healthy old age. Through a mechanistic understanding of the biological processes contributing to old age, methodology can be derived by which the increasingly older population of Americans is also an increasingly healthier population. Towards the goal of understanding the genetic and biochemical mechanisms promoting healthy longevity, this application proposes the utilization of the domestic dog for investigation of the free radical theory of aging. The working hypothesis is that oxidative stress contributes considerably to the aging process and specific mechanisms associated with aging and longevity can be determined by investigating the cellular and genetic differences between breeds with naturally diverse life span. The primary objective is to investigate the working hypothesis by examining the mechanisms through which oxidative stress may influence longevity in the dog. Because oxidative stressors have been demonstrated to affect longevity in other organisms (Kapahi et al, 1999; Campisi et al., 2001), it will be vital to elucidate the effects of the stressors in a mammalian system whose lifetime of medical care closely resembles the human's (Parker et al., 2004), yet has a life span significantly shorter than the human. Specifically, we determine 1) if oxidative stress levels are correlated to longevity within C. familiaris, 2) the level of gene expression of primary enzymes associated with diminishing cellular stress. Establishing this strong basis of knowledge regarding stress resistance in primary canine fibroblasts sets the stage for future more detailed investigations into the additional parameters within each biochemical pathway determined associated with longevity. Further, owner contact for the dogs is maintained, facilitating longitudinal data. PUBLIC HEALTH RELEVANCE: Life span in the American population has nearly doubled in the last century and it is becoming of greater importance both economically and socially, to understand the biological mechanisms of healthy old age. Through a mechanistic understanding of the biological processes contributing to old age, methodology can be derived by which our increasingly older population of Americans is also an increasingly healthy population. Towards the goal of undertanding the genetic and biochemical mechanisms promoting healthy longevity, this application proposes the utilization of a unique and genetically valuable mammal, the domestic dog, for investigation of the free radical theory of aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2011	PRAIRIE VIEW A & M UNIVERSITY	POST OFFICE BOX 667	PRAIRIE VIEW	TX	77446	WALLER	USA	Aging Research	000	3	8/14/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2011	PRAIRIE VIEW A & M UNIVERSITY	P.O. BOX 248	PRAIRIE VIEW	TX	77446	WALLER	USA	Aging Research	001	3	6/27/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$360,202
2014	2011	NORTH DAKOTA STATE UNIVERSITY	P.O. BOX 5405	FARGO	ND	58105	CASS	USA	Aging Research	000	2	6/26/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$360,202
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2011	INDIANA UNIVERSITY, EAST	2325 CHESTER BOULEVARD	RICHMOND	IN	47374	WAYNE	USA	Aging Research	000	1	2/5/2013	NEW	-$360,202
2013	2011	NORTH DAKOTA STATE UNIVERSITY	P.O. BOX 5405	FARGO	ND	58105	CASS	USA	Aging Research	001	2	2/6/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$360,202
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $360,202 )
2011	2011	INDIANA UNIVERSITY, EAST	2325 CHESTER BOULEVARD	RICHMOND	IN	47374	WAYNE	USA	Aging Research	000	1	9/27/2011	NEW	$360,202
														Subtotal = $360,202

Grand Total All Awards = $360,202

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Exploring mechanisms of aging in eukaryotes

Award Number: R15AG037158

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2011

PERIOD OF PERFORMANCE END DATE: 02/17/2014

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