2025 Cerebellum Gordon Research Conference and Gordon Research Seminar - PROJECT SUMMARY This proposal seeks partial funding for the 2025 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Cerebellum. The events will be held at Les Diablerets, Switzerland, a location chosen for both its seclusion for scientific exchange, its accessibility within a 4-hour flight from most of Europe, North Africa, and the Middle East, and easy access from the USA and Asia. The GRS, exclusively for trainees and managed by students and postdoctoral fellows, is scheduled for 7/5/25-7/6/25. The subsequent 5-day GRC, accommodating up to 200 participants, will run from 7/6/25-7/11/25. Recognized as the preeminent forum for cerebellar research, this conference unites a diverse international group of established investigators and trainees. The past five years have seen a substantial expansion of our understanding of the cerebellum's role beyond motor control to include cognitive functions. The 2025 GRC Cerebellum seeks to synthesize this remarkable progress with the firm and longstanding foundation established by the cerebellum as a motor-oriented brain structure. This dual role for the cerebellum provides the potential to provide conceptual linkages between movement disorders like ataxia, dystonia, and tremor to neuropsychiatric conditions such as autism spectrum disorder, ADHD, and schizophrenia. Our goal is to construct a novel, integrated framework for understanding cerebellar function by harnessing unique concepts and technologies from various disciplines to address challenging questions. The 2025 Cerebellum GRC will bring together advanced methodologies from molecular biology, physiology, anatomy, computation, and behavior. We have curated a diverse panel of 33 speakers (45% female, 24% early-stage investigator, 9% under-represented minorities). Each session is designed to tackle an unresolved problem, featuring a combination of speakers with expertise in neuroanatomy, developmental genetics, neurophysiology, disease mechanisms, and therapeutics. This integrated approach aims to stimulate lively and collegial participation from attendees at all career stages and across all disciplines. Both the GRS and GRC will feature talks by world-renowned keynote speakers. Poster sessions will provide a platform for attendees to present unpublished work. Additionally, we will host a Power Hour to promote diversity in cerebellar science and an informal session on grantsmanship and successful grant writing strategies. We are committed to fostering the future of women and underrepresented minorities in cerebellar research. The overarching theme of GRC Cerebellum 2025 is to leverage the field's breadth and depth to nurture the next generation of scientists. Through this conference, we aim to advance our understanding of the cerebellum's complex roles across many domains and its potential as a therapeutic target for many neurological and psychiatric conditions.