2020 Basal Ganglia Gordon Research Conference and Gordon Research Seminar - Project Summary/Abstract:
The basal ganglia are an intricately interconnected group of subcortical brain regions that are critical for the
motivation, selection, initiation, and execution of actions. Consistent with these roles, basal ganglia dysfunction
is linked to debilitating psychomotor disorders, including Parkinson’s disease, Huntington’s disease, dystonia,
addiction, obsessive compulsive disorder, and Tourette’s syndrome. The importance of the basal ganglia in
health and disease, together with the on-going development and evolution of approaches to probe their roles
and interactions, have motivated diverse research communities focused on these structures. Despite growing
interest in basal ganglia research, before the inaugural Basal Ganglia Gordon Research Conference (GRC) in
2014, the only conference focused on the basal ganglia was the triennial meeting of the International Basal
Ganglia Society (IBAGS), which is usually held outside the USA. Moreover, IBAGS meetings follow a typical
symposium format, which contrasts markedly with the interactive, discussion-oriented format of a GRC. Since
2016, the Basal Ganglia GRC has incorporated a 1.5 day Gordon Research Seminar (GRS) organized
exclusively by and for pre- and post-doctoral trainees. Beginning with the 2018 Basal Ganglia GRC & GRS,
these are now regular biennial meetings. The programs for the 2020 Basal Ganglia GRC & GRS were
designed by an interdisciplinary committee representing basic and clinical research in the field. A deliberate
effort was made to include new speakers and topics that were not included in the 2018 meeting, with the
overarching theme Basal Ganglia: From Thought to Action. Topics include cognition and decision making,
cellular plasticity in the basal ganglia, interactions within and beyond basal ganglia circuits, new computational
models, and clinically relevant freezing of gait.
The 2020 Basal Ganglia GRC and GRS have 3 specific aims: 1) move basal ganglia research forward by
featuring cutting-edge research in an interactive environment that encourages questions and discussion,
challenges current thinking, identifies open questions, and provides opportunities new collaborations; 2) model
diversity in basal ganglia research with respect to scientific approach and topics, gender balance, career stage,
and minority representation; and 3) provide opportunities for leadership, education, and mentoring for early
career scientists. Successful completion of these aims will advance basal ganglia research by encouraging
new ideas and collaborations, highlighting diversity in the field, and inspiring the next generation of scientists.
This should accelerate the pace of discovery and translation to the clinic, consistent with the mission of NIH.
