UC Irvine Center for Neural Circuit Mapping 2025 Conference: The Changing Brain - Project Summary / Abstract The UC Irvine Center for Neural Circuit Mapping (CNCM) focuses on anatomical, functional and omics analysis of neural circuits, and neurotechnology development. Our Center members are interested in defining molecular and neural mechanisms that underlie neurodevelopmental, neuropsychiatric and neurodegenerative disorders. We work collaboratively to establish transformative and translational research programs that focus on our ultimate goal to develop cures for human diseases of the nervous system. The CNCM has become a hub for cutting-edge technology and resource development in biomedical research. We disseminate our technology resources in coordination with our educational and research initiatives such as seminars, symposiums, and conferences. The 2025 summer conference “The Changing Brain” (August 18-21, 2025) jointly sponsored by the CNCM, Cajal Club and Allen Institute for Brain Science will be held in Irvine, California, USA; this will be our biggest conference yet with an increased focus on international reach. The 2025 meeting topics are timely and significant. The Scientific Program Committee led by Dr. Liqun Luo at Stranford University, has planned six sessions: 1) the Evolving Brain, 2) the Developing Brain, 3) the Learning Brain, 4) the Dynamic Brain, 5) States of the Brain, 6) the Disordered Brain. Our confirmed speakers represent a distinguished roster of leading researchers at various career stages in neuroscience. The speakers will offer diverse perspectives and in-depth insights on the theme of integrating the different facets of neural circuits. We expect vibrant discussions ranging from the latest technologies in neural circuit mapping to the implications of circuit dynamics in health and disease. In addition to the main conference proceedings, attendees will have opportunities to participate in onsite specialized workshops held on the UC Irvine campus. Workshops will offer more hands-on experiences that allow for deep dives into specific subtopics and methodologies in conjunction with specific interests of the attendees. Aligned to the NIMH mission, our meeting will promote the understanding and treatment of mental disorders through basic and clinical research, and will support communication between scientists, physicians, health-care providers, and the public about brain science advances and mental health research progress. We will comply with the NIMH policy, and requested NIMH funding will facilitate the attendance of students, trainees and members of underrepresented groups through waivered registration fees and travel awards.