Wednesday, April 2, 2025
4/2/2025
Hematopoiesis - ABSTRACT Support is requested for a Keystone Symposia conference entitled Hematopoiesis, organized by Drs. Trista North, Michael Kharas and Nina Cabezas-Wallscheid. The conference will be held in Copper, Colorado from February 25-28, 2024. Beyond the field’s primary focus on blood and bone marrow-related biology and disease, expanding research in hematology has contributed to fundamental shifts in areas such as our understanding of stem cell biology and the workings of the non-coding transcriptome and the epigenome, which have provided insights into the origins and treatment of diseases. Further, hematological cells have served as a testing ground for technological advancements such as therapeutic genome engineering and next-generation sequencing efforts for cancer diagnosis. Importantly, the development of targeted small molecule therapeutics and the introduction of immune- based cellular therapies have shown direct clinical benefits. This conference was developed to bring together biochemists, geneticists, molecular biologists and clinicians to bridge new insights into the biological mechanisms that control developmental hematopoiesis, hematopoietic stem cell biology and cell fate control with the diagnosis, progression and treatment of aging, inflammatory conditions and hematologic disorders and malignancies. This conference will highlight emerging technologies, including single cell multi-omics and imaging approaches, which are poised to fundamentally change our understanding of blood development and homeostasis and cellular engineering methods that have substantial potential for clinical applications. The conference will also feature emerging discoveries, such as insights into the role of clonal hematopoiesis that predisposes individuals to hematopoietic disease and leukemic transformation. Finally, the event will provide a platform for investigators from across disciplines and around the globe to establish productive collaborations and stimulate new ideas to enable substantial progress and address ongoing challenges in the hematology field.
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