Thursday, November 21, 2024
11/21/2024
Project Summary/Abstract The goal of this application is to obtain support for the American Chemical Society Division of Chemical Toxicology (TOXI) at the 264th 2022 National Meeting program, which will be held August 21-25, 2022, in Chicago, IL. The mission of the Division of Chemical Toxicology is to improve human health and public welfare by promoting the understanding of chemical mechanisms that govern disease processes and the toxicity of drugs, environmental agents, and endogenous chemicals. The Fall 2022 programming will focus on the “molecular mechanisms and predictions of environmental toxicological responses”. Our goals include providing a forum for communicating research in the field of chemical toxicology, encouraging research in chemical mechanisms of toxicity, and facilitating connections between academia, industry, and policy in scientific areas of mutual interest, as well as leadership and professional development of scientists at all levels. Thus, the requested funds will be used to support travel awards and expenses for graduate students, postdoctoral scholars, and junior faculty. The overall program is organized around the theme of “molecular mechanisms and predictions of environmental toxicological responses”. The program includes four thematic symposia, which will feature invited oral presentations by a diverse group of established and emerging investigators with a range of perspectives on each topic. The four thematic symposia are: (1) “A Developing Role for Artificial Intelligence (AI) in Drug Discovery in Drug Design, Development, and Safety Assessment”, co-promoted by the Divisions of Medicinal Chemistry (MEDI) and Computational Chemistry (COMP), will explore the role of AI in toxicological hazard identification and risk assessment; (2) “Current Approaches to COVID-19 Drug Discovery and Safety Assessment”, co-promoted with MEDI, will examine the therapeutic spectrum of pharmaceuticals and biologics and their associated safety efficacies; (3) “Mechanism-Driven Hazard Identification of Chemical Respiratory Allergens,” focuses on recent progress in development of in silico and in vitro methods to identify respiratory sensitizers and hazards; (4) “Chemical Biology of DNA Damage and Repair”, copromoted with the Division of Biological Chemistry (BIOL), describes recent advances in chemical biology approaches used to characterize the distribution of genome-wide lesions and molecular mechanisms of repair outcomes. The scientific program is clearly aligned with the mission of NIEHS.
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