Friday, October 24, 2025 10/24/2025

Biochemical Characterization of the CAMKV Pseudokinase

Award Number: R03TR004483
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2023
PERIOD OF PERFORMANCE END DATE: 05/31/2025

Group Awards By:

View Award Description

Biochemical Characterization of the CAMKV Pseudokinase - CAMKV is a brain specific pseudokinase and closely related to calmodulin regulated kinase 1 (CAMK1). Gene expression studies and genome wide association studies suggest a possible role of CAMKV in mental disorders, including post-traumatic stress disorder. CAMKV has been identified by the NIH – IDG initiative as a protein in need for additional research. The proposed research will contribute to the biochemical characterization of CAMKV by investigating its mechanism of regulation on the molecular level. In specific aim 1, ligands targeting the degenerated ATP binding pocket of CAMKV will be identified. Expected results, will provide insights in the cellular regulation of CAMKV by endogenous ligands and also identify small-drug like molecules as potential CAMKV inhibitors or activators. In specific aim 2, CAMKV interacting proteins will be isolated from brain tissue. Knowledge of CAMKV targets will be critically important to understand its role in normal neuronal tissue, as well as to provide a foundation for the role of CAMKV in mental diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$1,416 )
2025	2023	NORTH DAKOTA STATE UNIVERSITY	1340 ADMINISTRATION AVE	FARGO	ND	58105	CASS	USA	Trans-NIH Research Support	000	1	9/29/2025	NEW	-$1,416
														Subtotal = -$1,416

Issue Date FY: 2023 ( Subtotal = $145,000 )
2023	2023	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Trans-NIH Research Support	000	1	5/31/2023	NEW	$145,000
														Subtotal = $145,000

Grand Total All Awards = $143,584

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Biochemical Characterization of the CAMKV Pseudokinase

Award Number: R03TR004483

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2023

PERIOD OF PERFORMANCE END DATE: 05/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer