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Cognitive Impairment in Chronic Rhinosinusitis

Award Number: R03TR004005
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/04/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Cognitive Impairment in Chronic Rhinosinusitis - Abstract Cognitive impairment is characterized by problems with memory, language, thinking or judgment. Despite the tremendous known impact of impaired cognition on quality of life and individuals' health, beside our pilot study; impaired cognitive function associated with sleep timing disruption as its potential mechanisms, has not been objectively investigated in patients with inflammatory and allergic respiratory diseases such as Chronic rhinosinusitis (CRS). Our KL-2 supported studies and preliminary data have shown significant cognitive impairment in CRS patients compared to controls that was associated with sleep disturbance and sleep timing changes. Leveraging experienced gained through my KL2, the overall objectives of this proposed study are to: (1) characterize cognitive function profile in both healthy controls and patients with chronic inflammation in upper airways ; and identify those at risk of impaired cognition; (2) identify the preventable risk factors of cognitive impairment including sleep timing shift, (3) test the hypothesis that serum IL-6 has a role in this process and may serve as a biomarker for cognitive impairment in CRS. We have already recruited 124 individuals (69 CRS and 55 controls) for our pilot data and will plan to recruit additional study subjects and complete the data acquisition for all these cases to perform a case control study of 100 CRS patients and 100 controls. Aim 1 will characterize the cognitive function profile analyzing 6 domains of cognitive function in this case-control study of patients with CRS of varied severity compared to matched healthy controls; and also aims to identify risk factors of cognitive impairment in CRS. The potential risk factors we plan to study include demographics, socioeconomic and CRS-severity factors; and CRS-related comorbidities (atopy, asthma, etc.). Aim 2 focuses to test the hypothesis that a sleep-timing shift is linked to cognitive function impairment in CRS. Objective measurements of sleep timing including 7 days actigraphy and circadian rhythm assessment questionnaires will be performed in above 100 CRS and 100 control patients. A four-step statistical approach in which a series of regression analysis are conducted will be applied to test whether the effect of CRS severity on cognitive function is mediated by sleep. Aim 3 focuses to test the hypothesis that serum IL-6 is a valid biomarker for cognitive impairment in CRS. For this aim serum IL-6 level will be determined and related to cognitive variables in patients, using a multi-variate statistical model. If IL-6 is found to have a significant mediation, then sleep variables will be added in the regression analysis to explore how they work together to affect the association between IL-6 and cognition. Other inflammatory cytokines and soluble IL-6 receptor will also be measured to test related hypotheses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$30,421 )
2026	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	National Center for Advancing Translational Sciences	000	3	11/21/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$30,421
														Subtotal = -$30,421

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	National Center for Advancing Translational Sciences	001	3	2/14/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$41,259
2025	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	National Center for Advancing Translational Sciences	000	2	2/14/2025	NON-COMPETING CONTINUATION	-$41,259
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = -$56 )
2024	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	National Center for Advancing Translational Sciences	000	2	6/26/2024	NON-COMPETING CONTINUATION	-$4,408
2024	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	National Center for Advancing Translational Sciences	001	3	6/26/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$4,352
														Subtotal = -$56

Issue Date FY: 2023 ( Subtotal = $79,000 )
2023	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	National Center for Advancing Translational Sciences	000	2	5/26/2023	NON-COMPETING CONTINUATION	$79,000
														Subtotal = $79,000

Issue Date FY: 2022 ( Subtotal = $79,000 )
2022	2022	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	National Center for Advancing Translational Sciences	000	1	7/4/2022	NEW	$79,000
														Subtotal = $79,000

Grand Total All Awards = $127,523

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Cognitive Impairment in Chronic Rhinosinusitis

Award Number: R03TR004005

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/04/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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