Sustainable Software Tools for Neuromodulation Prediction - Project Summary/Abstract SCIRun, is an open-source problem solving environment that was developed in previous NIH-funded projects to enable all aspects of bioelectric field simulation, with a special emphasis on applications to neuromodulation and stimulation of the brain. Many advancements in transcranial (TMS, tCS) and invasive stimulation (DBS, sEEG, ECoG) have relied on computational simulation and optimization methods and many have used SCIRun to perform these simulations. However, SCIRun’s capabilities have fallen behind as stimulation methods have expanded (e.g., more complex stimulation electrodes with different sizes and numbers of electrodes). Moreover, any software product, especially with the complexity of SCIRun, also requires constant updates to remain com- patible with emerging operating systems and support libraries. We propose major upgrades and expansions of SCIRun through technological, infrastructure, interface, and training advancements. These improvements will make the package more efficient, flexible, and comprehensive. We will strongly broaden its use cases for scientists by developing new stimulation methods that may improve treatment outcomes and reduce costs for a range of pathologies. These improvements are also specifically aimed at making SCIRun more accessible to clinicians who can use our tools for individualized treatment planning and increased patient understanding. Of special interest will be applications in neuromodulation, a domain with vibrant growth in the exploration of novel electrode configurations and target interventions. To support these specific innovations will require improve- ments to the general software environment to reflect contemporary computing resources. Such changes in the research computing ecosystem provide opportunities for pipeline integration, distribution, and democratization of computing access. Changes that we wish to leverage include the explosion of Python as a development environment, which has seen considerable investment in infrastructure, support, capabilities, and distribution that remain open source and accessible. Similarly, improvements in cloud computing, web applications, and deployment technology have made these avenues more accessible. In addition to improving capabilities, inter- operability, and distribution, leveraging these open-source tools and ecosystems will connect us to active user communities, providing further opportunities for exposure, support, and sustainable benefits.
