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Small Focus/Transparent Transducers for Transcranial Ultrasound Stimulation in Mice

Award Number: R03NS144995
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Small Focus/Transparent Transducers for Transcranial Ultrasound Stimulation in Mice - Project Summary Human neuroscience does not currently have a noninvasive tool to focally modulate activity anywhere in the brain. This is a critical unmet need: without a focal brain-wide neuromodulation technique, hypotheses on neural circuit function generated from neuroimaging and behavioral studies remain correlational, and circuit-based treatments for central nervous system disease are limited by lack of depth and anatomical speciﬁcity. Transcranial Ultrasound Stimulation (TUS) is rapidly emerging a powerful tool for neuroscience and clinical applications. However, the mechanisms, targeting performance, and efﬁcacy are currently not well understood. Mice are the ideal model system to study the biophysics of these processes, using well developed tools based on genetically encoded calcium indicators (GCaMPs). The goal of this research is to use an innovative ultrasound transducer that provides an order of magnitude smaller focal spots at frequencies relevant to humans and therefore enabling technology for research in mice. We then use this transducer to obtain preliminary data with a novel paradigm, based on hippocampal slice data, to probe whether there is a state dependency of TUS to the visual cortex.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $154,274 )
2026	2026	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/18/2026	NEW	$154,274
														Subtotal = $154,274

Grand Total All Awards = $154,274

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Small Focus/Transparent Transducers for Transcranial Ultrasound Stimulation in Mice

Award Number: R03NS144995

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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