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Elucidating the role of kcnn1 in recovery from spinal cord injury

Award Number: R03NS136719
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/22/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Elucidating the role of kcnn1 in recovery from spinal cord injury - ABSTRACT Potassium channel proteins are involved in many aspects of human physiology. Small conductance calcium-activated potassium channels (SK channels) are voltage-independent and widely expressed in excitable cells. Our laboratory determined that expression of kcnn1, which encodes the SK1 channel, is upregulated after spinal cord injury in zebrafish. Our preliminary data using a potassium channel inhibitor, 4-aminopyridine, demonstrates that inhibition enhances swim recovery in zebrafish suggesting modulation of SK channels may be potentially useful as a therapeutic approach for SCI. The broad, long-term objective of the project is to determine the role of SK1 in recovery from spinal cord injury (SCI). To achieve this goal, we will first construct knockout and transgenic zebrafish for both paralogs of the SK1 channel. We will determine whether these lines properly develop a spinal cord and use optogenetic techniques to spatiotemporally control kcnn1 expression after SCI. Second, we will use pharmacological approaches to determine how modulation of SK channels mediates functional recovery after SCI. These studies will clarify the role of SK channels and specifically SK1 in recovery from SCI. We expect that the developed lines will be useful to study additional neurological pathologies and facilitate drug screening to identify new therapeutics for neurodegenerative diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $75,500 )
2025	2025	EAST CAROLINA UNIVERSITY	1000 E 5TH ST	GREENVILLE	NC	27858	PITT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/10/2025	NON-COMPETING CONTINUATION	$75,500
														Subtotal = $75,500

Issue Date FY: 2024 ( Subtotal = $75,500 )
2024	2024	EAST CAROLINA UNIVERSITY	1000 E 5TH ST	GREENVILLE	NC	27858	PITT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/22/2024	NEW	$75,500
														Subtotal = $75,500

Grand Total All Awards = $151,000

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Elucidating the role of kcnn1 in recovery from spinal cord injury

Award Number: R03NS136719

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/22/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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