Tuesday, April 23, 2024 4/23/2024

Evaluating EEG as a diagnostic and prognostic biomarker in Malawian children with febrile coma

Award Number: R03NS124536
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Coma with fever is a common clinical presentation for children living in resource-limited countries. In endemic areas, malaria is the most common cause. We previously established that EEG is a prognostic biomarker in pediatric cerebral malaria (CM). In this research, we will use data previously collected as part of an observational study enrolling Malawian children with non-malarial coma to identify if EEG is a diagnostic and prognostic biomarker in this patient group. We will evaluate whether there are differences in EEG studies in children with non-malarial coma and CM (a diagnostic biomarker). We will evaluate if there are EEG factors associated with hospital discharge outcomes in children with non-malarial febrile coma (a prognostic biomarker), as we did in our previous studies from children with CM. If EEG factors are associated with outcomes in children with non-malarial coma, we will compare them to the EEG factors associated with outcomes in children with CM. The results of this research may allow better clinical care of children with febrile coma, as it may help determine if the underlying cause of illness is malaria or non-malarial. It may help determine, at the time of admission, if a child with non-malarial coma is at higher risk of an adverse outcome.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $91,000 )
2024	2024	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/8/2023	NON-COMPETING CONTINUATION	$91,000
														Subtotal = $91,000

Issue Date FY: 2023 ( Subtotal = $91,000 )
2023	2023	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/5/2023	NEW	$91,000
														Subtotal = $91,000

Grand Total All Awards = $182,000

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Evaluating EEG as a diagnostic and prognostic biomarker in Malawian children with febrile coma

Award Number: R03NS124536

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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