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Intrinsic Functional Architecture of Dentate Nuclei in Autism Spectrum Disorder

Award Number: R03MH121879
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2024
PERIOD OF PERFORMANCE END DATE: 10/31/2024

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Intrinsic Functional Architecture of Dentate Nuclei in Autism Spectrum Disorder - Summary/Abstract Functional neuroanatomy in human dentate nucleus (DN) remains largely unmapped. Functional magnetic resonance imaging research has redefined broad categories of functional division in the human brain showing that primary processing, attentional “task positive” processing, and default-mode “task negative” processing are three central poles of neural macro-scale specialization. This new macro-scale understanding of the range and poles of brain function has revealed that not only cerebral cortex, but also thalamus, striatum, and cerebellar cortex contribute to the full spectrum of human neural organization. Whether functional specialization in DN obeys a similar set of macroscale divisions, and whether DN is yet another compartment of full-spectrum representation of human brain function remains unknown. This proposal aims to explore functional territories in human DN. Preliminary results using data-driven gradient-based clustering analysis reveal three functional zones as indexed by high spatio-temporal resolution resting-state MRI, and that these three distinct territories contribute uniquely to default-mode, salience-motor, and visual brain networks. Our goal is to replicate the results in an independent larger sample to provide a systems neuroscience substrate for cerebellar output to influence all broad categories of neural control – namely default-mode, attentional, and multiple unimodal streams of information processing including motor and visual. The overarching aim of this proposal is to apply these functional territories towards clinical translation, specifically in the context of Autism Spectrum Disorder.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2020	THE CARLE FOUNDATION	611 W PARK ST	URBANA	IL	61801	CHAMPAIGN	USA	Mental Health Research Grants	000	2	2/19/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2020	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Mental Health Research Grants	001	3	2/19/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $9,141 )
2024	2020	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Mental Health Research Grants	001	3	8/8/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$107,089
2024	2020	THE CARLE FOUNDATION	611 W PARK ST	URBANA	IL	61801	CHAMPAIGN	USA	Mental Health Research Grants	000	2	8/8/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$97,948
														Subtotal = $9,141

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	CARLE FOUNDATION, THE	611 W PARK ST	URBANA	IL	61801	CHAMPAIGN	USA	Mental Health Research Grants	000	2	5/10/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = -$10,195 )
2022	2020	CARLE FOUNDATION, THE	611 W PARK ST	URBANA	IL	61801	CHAMPAIGN	USA	Mental Health Research Grants	001	2	3/21/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$146,804
2022	2020	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	002	1	9/7/2022	NEW	-$1
2022	2020	CARLE FOUNDATION, THE	611 W PARK ST	URBANA	IL	61801	CHAMPAIGN	USA	Mental Health Research Grants	003	2	9/7/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1
2022	2020	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	1	3/21/2022	NEW	-$156,999
														Subtotal = -$10,195

Issue Date FY: 2020 ( Subtotal = $157,000 )
2020	2020	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	001	1	5/20/2020	NEW	$0
2020	2020	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	1	5/8/2020	NEW	$157,000
														Subtotal = $157,000

Grand Total All Awards = $155,946

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Intrinsic Functional Architecture of Dentate Nuclei in Autism Spectrum Disorder

Award Number: R03MH121879

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2024

PERIOD OF PERFORMANCE END DATE: 10/31/2024

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