Tuesday, September 30, 2025 9/30/2025

Expanding BioThings as a community API gateway for sharing biomedical knowledge

Award Number: R03LM014974
ORGANIZATION: NATIONAL LIBRARY OF MEDICINE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Expanding BioThings as a community API gateway for sharing biomedical knowledge - In biomedical research, effective analysis of new experimental data depends on the contextualization of results using the totality of biomedical knowledge known to date. This existing knowledge is often organized in structured knowledge bases (KBs). These KBs are instrumental in interpreting new data, and subsequent conclusions are often integrated back into the KBs to stimulate future discoveries. This positive-feedback loop has benefited multiple areas of biomedical research, given the rich availability of both high-throughput data and derived knowledge in recent decades. While development of technologies for data generation remains a primary way to drive research forward, improvements to the efficiency of making available data/knowledge Findable, Accessible, Interoperable and Reusable (FAIR) also has a significant impact for the future advancement in biomedical research. In this proposal, we propose to build a distributed ecosystem of biomedical Application Programming Interfaces (APIs) for promoting FAIR data-sharing and knowledge integration. This ecosystem contains a framework for API creation; an API registry for API management and discovery; and a semantic annotation and integration framework to create cross-API interoperability for their reuse. Beyond promoting the FAIR principles, the distributed nature of this API-based data ecosystem also allows distributed implementation and maintenance efforts for its long-term sustainability. The utility of the ecosystem will be demonstrated in broad areas of research use-cases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $276,000 )
2025	2025	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Medical Library Assistance	000	1	8/25/2025	NEW	$276,000
														Subtotal = $276,000

Grand Total All Awards = $276,000

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Expanding BioThings as a community API gateway for sharing biomedical knowledge

Award Number: R03LM014974

ORGANIZATION: NATIONAL LIBRARY OF MEDICINE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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