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Intravascular Ultrasonic Tissue Ablation (IVUS-TA) for Treatment of In-stent Restenosis

Award Number: R03EB040286
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/02/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Intravascular Ultrasonic Tissue Ablation (IVUS-TA) for Treatment of In-stent Restenosis - ABSTRACT In-stent restenosis (ISR) remains a major clinical challenge following percutaneous coronary intervention (PCI), leading to recurrent vessel narrowing and impaired blood flow despite the widespread use of drug-eluting stents. Current treatment options—such as balloon angioplasty, atherectomy, and repeat stenting—often result in limited luminal gain, vessel injury, and high recurrence rates. This project aims to develop a novel intravascular ultrasonic tissue ablation (IVUS-TA) technique capable of precisely and safely removing neointimal tissue and residual plaques within stents through localized high-intensity ultrasound energy delivery. By integrating a miniaturized high-frequency ultrasound transducer into a catheter platform, IVUS-TA enables direct, catheter- based energy deposition through metallic stent struts while minimizing collateral damage to surrounding tissues. The proposed studies will characterize the acoustic performance, thermal effects, and tissue ablation efficacy of the IVUS-TA system using ex-vivo and phantom models. Successful completion of this project will establish a minimally invasive therapeutic modality for ISR treatment and provide foundational data for future pre-clinical translation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $73,776 )
2026	2026	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/2/2026	NEW	$73,776
														Subtotal = $73,776

Grand Total All Awards = $73,776

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Intravascular Ultrasonic Tissue Ablation (IVUS-TA) for Treatment of In-stent Restenosis

Award Number: R03EB040286

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/02/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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