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A Simulation Framework for X-Ray Phase-Contrast Imaging

Award Number: R03EB032038
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2024

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A Simulation Framework for X-Ray Phase-Contrast Imaging - X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, we do not yet have a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale. In this study, we propose to develop such a simulation framework to accomplish this using the breakthroughs in two main components: a realistic human-scaled numerical phantom for XPCI, and a wave optics-based simulator for accurately propagating X-ray wave through a realistic human numerical phantom. For the numerical phantom, the biggest challenges are to incorporate various organs with multi- scale structures in a human-size phantom and to define material properties for human body parts under normal and a variety of pathophysiological conditions. To address these issues, we will extend the XCAT phantom, a human phantom that is widely used in medical imaging simulation, to incorporate sub-organ structures and tissue textures, and to assign appropriate material properties to various tissues for XPCI simulation. For the simulator, we have recently demonstrated the possibility of XPCI simulation at a human scale by applying a wave optics-based imaging model to XCAT phantom. In the proposed project, we will develop a general-purpose XPCI simulator that can be used with variety of geometries, X-ray optics, and tissue models. Using the data we have already acquired on a synchrotron-based, high-performance XPCI setup, we will validate the simulator so that its predictions match experimentally acquired data. Finally, we will distribute the program with a graphical user interface in order that the users can easily simulate their own XPCI systems. Source codes and a detailed user manual will be distributed as well.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	2/5/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/24/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $179,294 )
2021	2021	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/31/2021	NEW	$179,294
														Subtotal = $179,294

Grand Total All Awards = $179,294

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A Simulation Framework for X-Ray Phase-Contrast Imaging

Award Number: R03EB032038

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2024

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