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Defining a novel function for salivary exosomes in modulating host immunity against cancer

Award Number: R03DE029272
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/03/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2023

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Defining a novel function for salivary exosomes in modulating host immunity against cancer - Project Summary/Abstract Extracellular vesicles (EVs) have gained considerable attention as mediators of intercellular signaling and as potential sources of cancer biomarkers. Exosomes, which are nanoscale EVs of endocytic origin, are present in nearly all types of biofluids, carrying a tremendous potential for liquid biopsy and therapeutic applications. Exosomes deliver cargo containing immunoregulatory molecules such as receptors, ligands, antigens, and/or cytokines. This cargo can be reflective of the cell of origin and have effects on recipient cells. Salivary exosomes have been identified as highly informative nanovesicles with clinically relevant information. Salivary exosomes have brought forth a pathway and mechanism in which tumor-derived biomarkers can be shuttled through the systemic circulating into the oral cavity. Despite such clinical potential, the role of salivary exosomes for the host and tumor has been greatly understudied. We hypothesize that salivary exosomes have immunomodulatory effects through mucosal immune system. In this project, we will determine the unique peptide repertoire loading salivary exosomes in the setting of tumor. Identifying the salivary peptides that can activate or inhibit lymphocytes will provide new insights into the immune control of tumor and may uncover novel targets and strategies for immunotherapeutics. Moreover, identifying novel tumor- or host-derived antigens released into saliva will provide not only insight into its potential regulatory function but also the diagnostic value.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Oral Diseases and Disorders Research	000	3	1/24/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Oral Diseases and Disorders Research	000	2	10/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = -$6,984 )
2022	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Oral Diseases and Disorders Research	000	2	2/10/2022	NON-COMPETING CONTINUATION	-$108,965
2022	2021	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Oral Diseases and Disorders Research	001	3	2/11/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$101,981
														Subtotal = -$6,984

Issue Date FY: 2021 ( Subtotal = $156,000 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Oral Diseases and Disorders Research	000	2	3/4/2021	NON-COMPETING CONTINUATION	$156,000
														Subtotal = $156,000

Issue Date FY: 2020 ( Subtotal = $156,000 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Oral Diseases and Disorders Research	000	1	1/13/2020	NEW	$156,000
														Subtotal = $156,000

Grand Total All Awards = $305,016

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Defining a novel function for salivary exosomes in modulating host immunity against cancer

Award Number: R03DE029272

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/03/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2023

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