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Mixed Lineage Kinase 2 (MLK2) in tumor angiogenesis

Award Number: R03CA295675
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2025
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Mixed Lineage Kinase 2 (MLK2) in tumor angiogenesis - Project Summary Cancer is one of the leading causes of death in the USA. The study examines the role of Mixed Lineage Kinase 2 (MLK2) in tumor angiogenesis, a process vital for cancer growth. Hypoxic condition in solid tumor activates stress pathway of MLK2. MLK2, abundantly present in the endothelium, is shown to be essential for endothelial proliferation, migration, and angiogenesis. Lack of MLK2 impairs tumor growth in mouse models and increases miR-146a levels, which suppresses angiogenic factors like VEGF, adversely affecting angiogenesis and endothelial cell proliferation. Given that miR-146a overexpression in endothelial cells leads to similar deficiencies, the study suggests that MLK2's regulatory effect on miR-146a is crucial for endothelial functions and tumor angiogenesis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $83,180 )
2026	2026	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Biology Research	001	2	4/16/2026	NON-COMPETING CONTINUATION	$8,318
2026	2026	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Biology Research	000	2	1/13/2026	NON-COMPETING CONTINUATION	$74,862
														Subtotal = $83,180

Issue Date FY: 2025 ( Subtotal = $83,180 )
2025	2025	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Biology Research	000	1	12/11/2024	NEW	$83,180
														Subtotal = $83,180

Grand Total All Awards = $166,360

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Mixed Lineage Kinase 2 (MLK2) in tumor angiogenesis

Award Number: R03CA295675

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2025

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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