Friday, December 19, 2025 12/19/2025

New approaches to study tumor microvesicles

Award Number: R03CA273469
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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New approaches to study tumor microvesicles - ABSTRACT Tumor-derived microvesicles (TMVs), a vesicle subtype in the family of extracellular vesicles (EVs), contain bioactive protein and nucleic acid cargoes and have emerged as important mediators of intercellular communication in the tumor microenvironment (TME). By virtue of their roles in the TME, EVs have been thought to support the spread of metastatic disease by promoting tumor expansion and tumor invasive activity, dampening immune responses, and facilitating angiogenesis. Thus, identifying and targeting molecules and signaling pathways that control EV biogenesis and/or function has the potential to lead to novel and complementary therapeutic strategies. Moreover, the discovery that EVs are found in circulation has heightened interest in these vesicles as promising diagnostic and prognostic platforms. Although we have learned a great deal about EV function over the past decade, there is need to learn much more about how the various EV subtypes are formed and how they engage and affect recipient cells in the TME. In particular, there is a critical need to define the cellular pathways and signaling mechanisms that underlie TMV biogenesis to better understand their paracrine properties and function. Relative to tumor exosomes, the other prominent EV subtype shed by tumor cells, we know significantly less about TMVs. Our understanding of the molecular principles that control TMV formation and cargo incorporation remains limited in large part due to limitations in isolating and precisely defining the molecular makeup of individual EV populations. To begin to explore the molecular mechanisms of TMV formation and release, we have adapted a biochemical screen for TMV proteomic studies aimed at identifying TMV- specific cargo and testing novel regulation of TMV biogenesis. The findings that result from this pilot study will form the basis of delineating and testing a mechanistic framework underlying TMV biogenesis and function in preclinical models of tumor progression. Given our experience and expertise, our laboratory is well position to carry out these investigations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$10 )
2026	2023	UNIVERSITY OF NOTRE DAME DU LAC	940 GRACE HALL	NOTRE DAME	IN	46556	ST JOSEPH	USA	Cancer Biology Research	000	2	12/16/2025	NON-COMPETING CONTINUATION	-$10
														Subtotal = -$10

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF NOTRE DAME DU LAC	836 GRACE HALL	NOTRE DAME	IN	46556	ST JOSEPH	USA	Cancer Biology Research	000	2	7/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $78,250 )
2023	2023	UNIVERSITY OF NOTRE DAME DU LAC	940 GRACE HALL	NOTRE DAME	IN	46556	ST JOSEPH	USA	Cancer Biology Research	000	2	8/23/2023	NON-COMPETING CONTINUATION	$78,250
														Subtotal = $78,250

Issue Date FY: 2022 ( Subtotal = $78,250 )
2022	2022	UNIVERSITY OF NOTRE DAME DU LAC	940 GRACE HALL	NOTRE DAME	IN	46556	ST JOSEPH	USA	Cancer Biology Research	000	1	8/9/2022	NEW	$78,250
2022	2022	UNIVERSITY OF NOTRE DAME DU LAC	940 GRACE HALL	NOTRE DAME	IN	46556	ST JOSEPH	USA	Cancer Biology Research	001	1	8/19/2022	NEW	$0
														Subtotal = $78,250

Grand Total All Awards = $156,490

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New approaches to study tumor microvesicles

Award Number: R03CA273469

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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