Sunday, February 15, 2026 2/15/2026

3D Chromatin Studies in Pediatric B Cells To Study the Genetics of Autoimmunity

Award Number: R03AI166892
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/01/2021
PERIOD OF PERFORMANCE END DATE: 10/31/2024

Group Awards By:

View Award Description

3D Chromatin Studies in Pediatric B Cells To Study the Genetics of Autoimmunity - Abstract – The purpose of this small project is to gather preliminary data we need to support a range of projects relating to autoimmunity in children, and particularly to pediatric systemic lupus erythematosus (pSLE). Specifically, we need to generate 3D chromatin maps on B cells from children in order to carry our work forward. The project also addresses the serious need for reference genomic data sets that can be used in a broad spectrum of research aimed at understanding childhood-onset, immune-driven diseases. The problem we face is a common one in pediatrics and limits our ability to rigorously pursue genetic and genomic translational studies: the uncertainty as to whether publicly available genomic data sets (e.g., from Roadmap Epigenomics) can be used as comparison data to interpret similar data generated in children. The limitations in the use public data sets therefore represent a “tax” on the research of pediatric investigators that is not always required of investigators studying adult or adult-onset diseases, where a broad variety of genomic data sets are already available, including those from diseased tissues. In this project, we will produce an reference data set that will be useful to a range of investigations into immune-based diseases that occur in children. Our work in pediatric autoimmune diseases is aimed at identifying causal variants on genetic risk haplotypes as well as the genes impacted by those variants. These target genes may not be those nearest the causal variant, or even genes on the risk haplotype. They will almost invariably be genes within the same chromatin loop or topologically associated domains, chromatin loop structures that are anchored by the CCCT binding factor (CTCF) and cohesin. Identifying these loop structures is therefore a key step in identifying target genes. This project is aimed to identify these structures, and the genes expressed within them, in pediatric samples. Our approach is straightforward. We will use CTCF Cut-and-Run and HiChIP to identify CTCF-anchored loop structures in the B cells of healthy children. We will also perform RNA sequencing on these same samples in order to identify the genes expressed within loops. At the completion of this 2-year project, we will have obtained the essential data that we need to rigorously interpret the studies we already have under way in pSLE and will have provided the field with an essential tool for future investigations into autoimmunity in children.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$21,715 )
2025	2023	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	000	2	4/16/2025	NON-COMPETING CONTINUATION	-$21,715
														Subtotal = -$21,715

Issue Date FY: 2023 ( Subtotal = $79,750 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	000	2	10/28/2022	NON-COMPETING CONTINUATION	$79,750
														Subtotal = $79,750

Issue Date FY: 2022 ( Subtotal = $79,750 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	000	1	10/25/2021	NEW	$79,750
														Subtotal = $79,750

Grand Total All Awards = $137,785

Top

All Categories

About

Search

Reports

Data Submission

Award Information

3D Chromatin Studies in Pediatric B Cells To Study the Genetics of Autoimmunity

Award Number: R03AI166892

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/01/2021

PERIOD OF PERFORMANCE END DATE: 10/31/2024

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer