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Phosphotyrosine Recognition in Bacteria

Award Number: R03AI137599
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/06/2018
PERIOD OF PERFORMANCE END DATE: 01/31/2020

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Phosphotyrosine Recognition in Bacteria - Abstract The recognition of posttranslational modifications by modular protein domains is a fundamental determinant of selectivity in signaling pathways. In particular tyrosine (Tyr) phosphorylation pathways are regulated by a large number of different, modular phosphotyrosine (pTyr) recognition domains such as SH2 and PTB domains that recognize pTyr and coordinate signaling events downstream of kinases. While in eukaryotes, several pTyr recognition domains have independently evolved and in humans, for example, there are more pTyr recognition domains than Tyr kinases, no pTyr recognition domains have been identified in bacteria. Yet, pTyr reader domains evolved repeatedly, are highly versatile, are highly integrated parts of phosphorylation pathways, and are nearly ubiquitous except in bacteria. Given the large networks of Tyr phosphorylation in bacteria, it appears likely that bacteria also evolved pTyr recognition domains that remain to be discovered. Here, we will test this idea by identifying pTyr-binding proteins in Mtb.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $1 )
2022	2018	SEATTLE BIOMEDICAL RESEARCH INSTITUTE	307 WESTLAKE AVE N STE 500	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	1	9/26/2022	NEW	$1
														Subtotal = $1

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	3	8/17/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $92,104 )
2019	2019	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	002	3	2/1/2019	NON-COMPETING CONTINUATION	$94,150
2019	2018	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	001	2	12/21/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$50,031
2019	2018	SEATTLE BIOMEDICAL RESEARCH INSTITUTE	307 WESTLAKE AVE N STE 500	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	003	1	4/30/2019	NEW	$0
2019	2018	SEATTLE BIOMEDICAL RESEARCH INSTITUTE	307 WESTLAKE AVE N STE 500	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	1	12/21/2018	NEW	-$52,077
														Subtotal = $92,104

Issue Date FY: 2018 ( Subtotal = $98,000 )
2018	2018	SEATTLE BIOMEDICAL RESEARCH INSTITUTE	307 WESTLAKE AVE N STE 500	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	1	2/5/2018	NEW	$98,000
														Subtotal = $98,000

Grand Total All Awards = $190,105

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Phosphotyrosine Recognition in Bacteria

Award Number: R03AI137599

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/06/2018

PERIOD OF PERFORMANCE END DATE: 01/31/2020

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