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Reduced allelic dosage of CLP1 attenuates cognitive dysfunction and pathological burden in transgenic mouse models of Alzheimer’s disease

Award Number: R03AG080287
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Reduced allelic dosage of CLP1 attenuates cognitive dysfunction and pathological burden in transgenic mouse models of Alzheimer’s disease - Project Summary/Abstract Alzheimer’s disease (AD) is the most prevalent form of dementia in the elderly caused by complex interactions of genetic and environmental risk factors. An estimated 130 million people will develop AD by 2050, constituting an urgent clinical need for effective treatments and therapies to be developed. Prior therapies have focused on resolving pathological hallmarks, such as senile plaques (Ab) and neurofibrillary tangles (tau), but have failed to improve cognitive function in patients. The RNA kinase, CLP1, was recently found to be a genetic mediator AD. Additionally, high mRNA levels of CLP1 correlated with poor cognitive function in patients. Our preliminary histological analysis of brain samples from dementia patients and a mouse model of AD, with controls, found a shared, aberrant expression pattern of CLP1 protein with disease. Together, these findings lead us to hypothesize that CLP1 overexpression may contribute to AD pathogenesis and cognitive decline in AD. To test this idea, we will intercross mouse models of AD with Clp1 heterozygous mutant mice and assess disease pathology and cognitive decline during AD progression for amelioration.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $155,205 )
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Aging Research	001	2	5/1/2024	NON-COMPETING CONTINUATION	$15,520
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Aging Research	000	2	11/6/2023	NON-COMPETING CONTINUATION	$139,685
														Subtotal = $155,205

Issue Date FY: 2023 ( Subtotal = $155,205 )
2023	2023	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Aging Research	000	1	11/17/2022	NEW	$155,205
														Subtotal = $155,205

Grand Total All Awards = $310,410

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Reduced allelic dosage of CLP1 attenuates cognitive dysfunction and pathological burden in transgenic mouse models of Alzheimer’s disease

Award Number: R03AG080287

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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