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Regulation of transcription termination and its link in mRNA surveillance

Award Number: R01TW008298
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2010
PERIOD OF PERFORMANCE END DATE: 11/30/2015

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Regulation of transcription termination and its link in mRNA surveillance - Precise regulation of transcription termination is essential to cellular growth and survival. While premature stopping of transcription may produce truncated and defective transcripts; stopping too late may disrupt the regulation of downstream genes in the same orientation and generate antisense RNA against genes in the opposite orientation. Either outcome would have significant impact on gene expression. Thus, it is not surprising that transcription termination defects are causally associated with various human diseases, such as thrombophilia, thalassemia and cancer. We have previously demonstrated in a recent study that the mRNA cap-binding protein complex functions in conjunction with antitermination factor Npl3p to regulate transcription termination. In this project, I will continue to shed light on the mechanisms of eukaryotic transcription termination in the model organism of budding yeast using a combination of genetic and molecular biological methods. My study will focus on the regulation of eukaryotic transcription termination through Npl3p and the functional coupling of eukaryotic transcription termination with RNA surveillance. For the first part, I will define the influence of post-translational modification of Npl3p on its antitermination activity. For the second part, I will explore how cellular machineries of transcription termination and RNA surveillance are functionally coupled with each other. Particularly, I will investigate cotranscriptional recruitment of nuclear exosome Rrp6p. Because of the fundamental importance of transcription termination and high degree of conservation of transcription termination machineries from yeast to human, our findings will have important implications in human diseases caused by transcription termination defects.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2015 ( Subtotal = $52,380 )
2015	2015	UNIVERSITY OF HONG KONG	ROOM G02 HUI OI CHOW SCI BLDG	HONG KONG				HKG	International Research and Research Training	000	5	12/8/2014	NON-COMPETING CONTINUATION	$52,380
														Subtotal = $52,380

Issue Date FY: 2014 ( Subtotal = $52,380 )
2014	2014	UNIVERSITY OF HONG KONG	ROOM G02 HUI OI CHOW SCI BLDG	HONG KONG				HKG	International Research and Research Training	001	4	3/18/2014	NON-COMPETING CONTINUATION	$25,380
2014	2014	UNIVERSITY OF HONG KONG	ROOM G02 HUI OI CHOW SCI BLDG	HONG KONG				HKG	International Research and Research Training	000	4	11/23/2013	NON-COMPETING CONTINUATION	$27,000
														Subtotal = $52,380

Issue Date FY: 2013 ( Subtotal = $51,300 )
2013	2013	UNIVERSITY OF HONG KONG	ROOM G02 HUI OI CHOW SCI BLDG	HONG KONG				HKG	International Research and Research Training	001	3	4/25/2013	EXTENSION WITH OR WITHOUT FUNDS	$24,300
2013	2013	UNIVERSITY OF HONG KONG	ROOM G02 HUI OI CHOW SCI BLDG	HONG KONG				HKG	International Research and Research Training	000	3	11/10/2012	EXTENSION WITH OR WITHOUT FUNDS	$27,000
														Subtotal = $51,300

Issue Date FY: 2012 ( Subtotal = $54,000 )
2012	2012	UNIVERSITY OF HONG KONG	ROOM G02 HUI OI CHOW SCI BLDG	HONG KONG				HKG	International Research and Research Training	001	2	3/9/2012	NON-COMPETING CONTINUATION	$27,000
2012	2012	UNIVERSITY OF HONG KONG	ROOM G02 HUI OI CHOW SCI BLDG	HONG KONG				HKG	International Research and Research Training	000	2	12/2/2011	NON-COMPETING CONTINUATION	$27,000
														Subtotal = $54,000

Issue Date FY: 2011 ( Subtotal = $54,000 )
2011	2011	UNIVERSITY OF HONG KONG	ROOM G02 HUI OI CHOW SCI BLDG	HONG KONG				HKG	International Research and Research Training	000	1	11/27/2010	NEW	$54,000
														Subtotal = $54,000

Grand Total All Awards = $264,060

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Regulation of transcription termination and its link in mRNA surveillance

Award Number: R01TW008298

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2010

PERIOD OF PERFORMANCE END DATE: 11/30/2015

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