Saturday, December 20, 2025 12/20/2025

Public Engagement for Gene Drive Technology

Award Number: R01TR003514
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2020
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Public Engagement for Gene Drive Technology - PROJECT SUMMARY Development of gene drives to control mosquito vectors of disease has rapidly accelerated in recent years, and these efforts may soon culminate in gene drive systems ready for open field testing. The success of gene drive and other novel vector control approaches will depend on design decisions, oversight, and plans for field testing and deployment that meet the needs of various stakeholders, including residents of affected areas and the general public, but there is little agreement about how best to obtain informed public input. In a recent analysis of engagement initiatives for novel vector control approaches, our group found that for many initiatives, there was a lack of documentation, and for initiatives that were documented, many had vaguely articulated goals that were not clearly linked to either the methods used or the stage of technological development. The goal of this study is to develop a robust conceptual framework for public engagement to guide the development of gene drives and other emerging technologies from early proof of concept through field trials to deployment. The framework we produce will be generalizable to other novel and exceptional technologies. Each aim of the proposed project is supported by prior published work conducted by our group and observations from preliminary data. In Specific Aim 1, we will conduct a systematic landscape analysis of engagement initiatives for existing novel genetic and other vector control technologies, including gene drive. In Specific Aim 2, we will formulate a public engagement framework that aligns stage of product development with engagement timing, methods, messages, and goals. In Specific Aim 3, we will obtain informed expert and public input on the engagement framework and use the input to refine and finalize the framework. This contribution will be significant because it will provide the foundation for a coherent and comprehensive approach to public engagement for gene drive and other novel and emerging technologies, thereby ensuring the successful translation of novel innovations to address critical public health problems. The approach is innovative in engaging both experts and a demographically and geographically diverse sample of members of the public, including both English and Spanish speakers. The work is feasible in our hands because our team of established investigators has a track record of successful multidisciplinary research projects related to public engagement for novel vector control interventions, as well as expertise in ethical, social, and policy issues related to gene drive.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	National Center for Advancing Translational Sciences	000	4	12/16/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $445,290 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	National Center for Advancing Translational Sciences	000	4	7/25/2023	NON-COMPETING CONTINUATION	$445,290
														Subtotal = $445,290

Issue Date FY: 2022 ( Subtotal = $456,429 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	National Center for Advancing Translational Sciences	002	3	7/21/2022	NON-COMPETING CONTINUATION	$456,429
2022	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	National Center for Advancing Translational Sciences	001	2	7/13/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	National Center for Advancing Translational Sciences	000	2	5/17/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $456,429

Issue Date FY: 2021 ( Subtotal = $457,970 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	National Center for Advancing Translational Sciences	000	2	8/11/2021	NON-COMPETING CONTINUATION	$457,970
														Subtotal = $457,970

Issue Date FY: 2020 ( Subtotal = $450,745 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	National Center for Advancing Translational Sciences	000	1	9/17/2020	NEW	$450,745
														Subtotal = $450,745

Grand Total All Awards = $1,810,434

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Public Engagement for Gene Drive Technology

Award Number: R01TR003514

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2020

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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