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EXPRESSION OF THE ZEBRAFISH GENOME DURING EMBRYOGENESIS

Award Number: R01RR015402
ORGANIZATION: NATIONAL CENTER FOR RESEARCH RESOURCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 02/05/2001
PERIOD OF PERFORMANCE END DATE: 06/30/2007

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EXPRESSION OF THE ZEBRAFISH GENOME DURING EMBRYOGENESIS - DESCRIPTION (provided by applicant): The long-term objective of this application for competing continuation of the grant (1R01 RR15402) is to make a complete description of the spatial and temporal expression of a vertebrate genome. The zebrafish (Danio rerio) is the model organism used to achieve this goal. This vertebrate species displays many technical advantages allowing high throughput analyses of gene expression patterns by whole mount in situ hybridization on developing embryos. The work funded by the current application has already allowed the screening of 13,000 cDNAs corresponding to 8,000 different genes. This application proposes to increase the size of the screen to analyse, in 3 years, the expression of 15,000 genes. All these data will be described and made available to public into the zebrafish community database at the University of Oregon (http://zfin.org). A precise description of gene expression patterns will be provided on this web site in the gene expression section. This description will include keywords, text and a set of annotated pictures of embryos at different developmental stages (from gastrulation stage to hatching). Genes identified in this study will also be freely available upon request at the zebrafish International Resource center. The resources generated in this project will provide a large collection of cell and/or tissue specific markers usable for the analysis of embryonic development and for the establishment of a "molecular anatomy". It will provide starting points for functional analyses (by gain or loss of function experiments and reverse genetic). Finally, many of the genes identified in this screen are orthologues of human genes of unknown function. The establishment of the spatial and temporal expression of these genes in fish will provide a first set of data that will help to analyze their function during mammalian embryonic development. This will provide insights to better understand both normal and pathological human development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $365,817 )
2006	2006	GIE-CERBM	1 RUE LAURENT FRIES BP 10142	ILLKIRCH				FRA	National Center for Research Resources	000	6	7/1/2006	NON-COMPETING CONTINUATION	$365,817
														Subtotal = $365,817

Issue Date FY: 2005 ( Subtotal = $363,711 )
2005	2005	GIE-CERBM	1 RUE LAURENT FRIES BP 10142	ILLKIRCH				FRA	National Center for Research Resources	000	5	6/27/2005	NON-COMPETING CONTINUATION	$363,711
														Subtotal = $363,711

Issue Date FY: 2004 ( Subtotal = $402,117 )
2004	2004	GIE-CERBM	1 RUE LAURENT FRIES BP 10142	ILLKIRCH				FRA	National Center for Research Resources	000	4	6/21/2004	COMPETING CONTINUATION	$402,117
														Subtotal = $402,117

Issue Date FY: 2003 ( Subtotal = $235,425 )
2003	2003	IGBMC						FR	Comparative Medicine	000	3		NON-COMPETING CONTINUATION	$235,425
														Subtotal = $235,425

Issue Date FY: 2002 ( Subtotal = $228,567 )
2002	2002	IGBMC						FR	Comparative Medicine	000	2	12/18/2001	NON-COMPETING CONTINUATION	$228,567
														Subtotal = $228,567

Issue Date FY: 2001 ( Subtotal = $301,910 )
2001	2001	IGBMC						FR	Comparative Medicine	000	1	2/1/2001	NEW	$301,910
														Subtotal = $301,910

Grand Total All Awards = $1,897,547

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EXPRESSION OF THE ZEBRAFISH GENOME DURING EMBRYOGENESIS

Award Number: R01RR015402

ORGANIZATION: NATIONAL CENTER FOR RESEARCH RESOURCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 02/05/2001

PERIOD OF PERFORMANCE END DATE: 06/30/2007

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