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Transplantation of Human iPSC Neurons for Cervical Spinal Cord Injury Repair

Award Number: R01NS141234
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/06/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Transplantation of Human iPSC Neurons for Cervical Spinal Cord Injury Repair - PROJECT SUMMARY Spinal cord injury (SCI) has a devastating outcome in humans, particularly cervical spinal cord injuries, as they result in the patient being severely impaired with significantly diminished (or no) use of their upper limbs. The repair of corticospinal tract (CST) axons is a major obstacle to the recovery of the adult spinal cord after an injury. Historically, CST axons following injury fail to regrow and retract rostrally from the original lesion site; therefore, any therapeutic intervention needs to offer a positive growth milieu and provide meaningful connections to the limbs once innervated. Developing a regenerative therapy for SCI would be transformational. Even small improvements in upper limb function will provide cervical injured patients a chance for increased independence. Establishing an effective cellular treatment for SCI would greatly reduce the significant and ongoing care costs to the US healthcare system. We have developed a reproducible in vitro differentiation protocol to produce deep cortical neurons, as a viable and promising cellular transplantation strategy for cervical SCI. We will employ a rat cervical contusion (C5 level) model of spinal cord injury to measure integration, survival, synaptic circuitry and functional outcomes following deep cortical neuron transplants at a single defined age point (Day 35). Our animals will also undergo additional behavioral/functional testing following deep cortical neurons transplantation. We hypothesize that our deep cortical neurons transplants successfully survive, integrate, and form appropriate functional and anatomical outcomes after a cervical spinal injury. We propose that any observed functional improvement will arise from the transplanted deep cortical neurons forming new connections to host spinal cord circuitry, and in addition, host CST axons will form synaptic connections to those neurons from the deep cortical neuron transplants. Functional tests encouraging the use of the injured forelimb and assessment will also be undertaken in groups to ascertain improved growth and target specificity. We believe our strategies will help patients with cervical spinal cord damage by using techniques that can be matched to the individual patient, reduce dependence on anti-rejection drugs and provide significant recovery capacity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $586,866 )
2026	2026	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/11/2026	NEW	$586,866
														Subtotal = $586,866

Grand Total All Awards = $586,866

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Transplantation of Human iPSC Neurons for Cervical Spinal Cord Injury Repair

Award Number: R01NS141234

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/06/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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