Thursday, December 4, 2025 12/4/2025

Non-Contrast-Enhanced MRI for Brain Perfusion Mapping of Lewy Body Dementia

Award Number: R01NS139369
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2024
PERIOD OF PERFORMANCE END DATE: 04/14/2025

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Non-Contrast-Enhanced MRI for Brain Perfusion Mapping of Lewy Body Dementia - Project Abstract Cognitive impairment is a significant non-motor symptom of Parkinson's disease (PD). At least 75% of PD patients surviving for more than 10 years will develop Parkinson’s disease dementia (PDD) and the incidence rate of dementia in PD is 4-6 times of the general population. PDD and dementia with Lewy bodies (DLB), jointly known as Lewy body dementia (LBD), are both caused by abnormal deposits of proteins in the brain called Lewy bodies, and account for 4-10% of all dementia patients. Cerebral blood flow (CBF) is considered an important biomarker for neurodegeneration. There remains an urgent unmet need to establish reliable and practical neuroimaging biomarkers related to cognitive functions to describe both the spatial and temporal progression of LBD. Arterial spin labeling (ASL) is a completely noninvasive method for measuring CBF and is ideal for frequent non-invasive longitudinal monitoring. ASL methods typically apply spatially selective inversion modules to supply arteries distant from imaging volumes, which is known to render underestimation of CBF due to transit time delay, especially among elderly subjects. Velocity-selective arterial spin labeling (VSASL) was proposed to remove the time-delay artifact. Our group has implemented the first velocity-selective inversion (VSI) based VSASL with 3D segmented GRASE acquisition and demonstrated its higher sensitivity to perfusion signal over conventional ASL methods. Furthermore, our preliminary data showed that VSASL with 3D single-shot stack-of-spiral-based turbo FLASH acquisition delivered better perfusion image quality with fewer artifacts than using segmented GRASE, and high temporal resolution potentially allowing adequate retrospective motion correction. The overarching goal is to test the hypothesis that the VSASL-based CBF pattern is a reliable biomarker for LBD that predicts long-term cognitive impairment and dementia outcomes: Aim 1, we will conduct further technical developments for 3D VSASL with accelerated acquisitions and improved immunity to head motion; Aim 2, we will assess VSASL’s between- session reproducibility and its reliability to detect regional changes in CBF related to movement tasks and the dopaminergic medication; Aim 3, we will investigate VSASL’s sensitivity to early cognitive impairment in patients leading to LBD through both cross-sectional and longitudinal comparisons. These studies are to ensure the optimized VSASL MRI technique with high reproducibility, reliability, and sensitivity to detect early changes in brain perfusion that are correlated with cognitive impairment and dementia in patients leading to LBD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	12/2/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2026	2024	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	11/25/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $440,126 )
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	9/23/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$440,126
2025	2024	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/23/2025	NEW	$0
														Subtotal = $440,126

Issue Date FY: 2024 ( Subtotal = $420,683 )
2024	2024	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/17/2024	NEW	$420,683
														Subtotal = $420,683

Grand Total All Awards = $860,809

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Non-Contrast-Enhanced MRI for Brain Perfusion Mapping of Lewy Body Dementia

Award Number: R01NS139369

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2024

PERIOD OF PERFORMANCE END DATE: 04/14/2025

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