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Dopaminergic Modulation of Hippocampal-Cortical Interactions in Learning

Award Number: R01NS135465
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2028

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Dopaminergic Modulation of Hippocampal-Cortical Interactions in Learning - PROJECT SUMMARY The hippocampus plays a critical role in the formation of episodic memories. The current predominant hypothesis is that memories are gradually established across distributed cortical networks under the influence of hippocampal activity. Dopamine influences memory processing by signaling the motivational salience of behaviorally relevant stimuli and by modulating the plasticity of cortical and hippocampal circuits. However, our understanding of the impact of hippocampal inputs and dopaminergic modulation on cortical circuits during memory processing remains incomplete. Here we propose to use two-photon imaging to characterize the evolution of hippocampal inputs, dopamine dynamics, and neuronal responses in the auditory cortex throughout the formation of associative auditory memories. In addition, we will measure the plasticity of hippocampal inputs and their modulation by dopamine in vivo. Finally, we propose to use a combination of optogenetic and pharmacological perturbations of the hippocampal inputs and dopamine levels in the auditory cortex to determine their functional role in the learning and consolidation of auditory memories. Characterizing hippocampal-cortical interactions and their neuromodulation is of fundamental importance for understanding the circuit mechanisms underlying memory formation and can provide the foundation for elucidating how these mechanisms are perturbed in memory disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $510,444 )
2026	2026	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	12/23/2025	NON-COMPETING CONTINUATION	$510,444
														Subtotal = $510,444

Issue Date FY: 2025 ( Subtotal = $506,794 )
2025	2025	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	11/8/2024	NON-COMPETING CONTINUATION	$506,794
														Subtotal = $506,794

Issue Date FY: 2024 ( Subtotal = $579,005 )
2024	2024	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	12/12/2023	NEW	$579,005
														Subtotal = $579,005

Grand Total All Awards = $1,596,243

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Dopaminergic Modulation of Hippocampal-Cortical Interactions in Learning

Award Number: R01NS135465

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2028

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