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Overcoming the Barriers to Effective Transcranial Temporal Interference Stimulation in Humans

Award Number: R01NS133229
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/10/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Overcoming the Barriers to Effective Transcranial Temporal Interference Stimulation in Humans - Project Summary/Abstract One in three patients across neurological and psychiatric disorders are treatment resistant. Neuromodulation could provide these patients with treatment options, but current invasive approaches carry significant risk, while noninvasive approaches have low spatial resolution and cannot stimulate deep brain areas. Transcranial temporal interference stimulation (TIS) is emerging as a novel tool that combines noninvasiveness with favorable focus, high focusing flexibility, and the possibility to stimulate at depth. Successful applications to deep brain targets as well as flexible focusing have been demonstrated in mice. This proposal takes the critical set of next steps so that TIS can be effectively applied to the human brain. In Aim 1, we will realize the key strength of TIS, applying it to deep brain nuclei of non-human primates. In a controlled experiment, we will determine the intensity threshold that produces substantial effects on visual choice behavior, and validate the safety of the stimulation. In Aim 2, we will apply TIS to the motor cortex of humans and use an established method to elicit and measure motor evoked potentials in relation to the phase of the TIS waveform. Using this metric, we will i) validate that effects of TIS are due to the beat pattern and not the carrier, ii) evaluate the effect of the TIS carrier frequency, and iii) devise protocols for transient and sustained neuromodulation. Together, our work provides protocols for effective and safe TIS modulation of the human brain. This development has the potential to provide noninvasive and spatially specific treatment options to the large number of patients with brain disorders that are resistant to, our counter-indicated for, existing forms of treatments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $584,510 )
2025	2025	UNIVERSITY OF MASS AT BOSTON	100 WILLIAM T MORRISSEY BLVD	DORCHESTER	MA	02125	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	7/2/2025	NON-COMPETING CONTINUATION	$584,510
														Subtotal = $584,510

Issue Date FY: 2024 ( Subtotal = $564,970 )
2024	2024	UNIVERSITY OF MASS AT BOSTON	100 WILLIAM T MORRISSEY BLVD	DORCHESTER	MA	02125	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	7/8/2024	NON-COMPETING CONTINUATION	$564,970
2024	2023	UNIVERSITY OF MASS AT BOSTON	100 WILLIAM T MORRISSEY BLVD	DORCHESTER	MA	02125	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	6/13/2024	NEW	-$624,795
2024	2023	UNIVERSITY OF MASS AT BOSTON	100 WILLIAM T MORRISSEY BLVD	DORCHESTER	MA	02125	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	6/24/2024	NEW	$624,795
														Subtotal = $564,970

Issue Date FY: 2023 ( Subtotal = $624,795 )
2023	2023	UNIVERSITY OF MASSACHUSETTS	100 MORRISSEY BLVD RM 80	BOSTON	MA	02125	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/7/2023	NEW	$624,795
														Subtotal = $624,795

Grand Total All Awards = $1,774,275

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Overcoming the Barriers to Effective Transcranial Temporal Interference Stimulation in Humans

Award Number: R01NS133229

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/10/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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