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CRCNS: Dynamics of thalamocortical networks during sensory discrimination

Award Number: R01NS130919
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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CRCNS: Dynamics of thalamocortical networks during sensory discrimination - Thalamocortical networks are critical for basic neural sensory processing and for foundational cognitive functions such as attention, perception, and working memory. Dysfunction of these networks is thought to affect symptomology of several neurological disorders and some psychiatric disorders; however, the dynamics of thalamocortical networks during everyday tasks are poorly understood even in healthy cognitive function. The thalamus is a complex aggregation of nuclei with distinct roles and connection patterns. Fundamental questions remain regarding how these many distinct nuclei interact with the various sensory, motor and association areas in cortex. In particular, the roles of higher-order thalamic nuclei, each of which projects diffusely across several cortical regions, and the role of the thalamic reticular nucleus, which inhibits most other thalamic nuclei, remain poorly understood. In order to clarify the dynamic interactions within thalamocortical networks, this study will measure activity in all dorsal regions of cortex and in many thalamic nuclei during a variety of sensory discrimination tasks, similar to those tasks commonly used for studies of cognitive function in health and disease. We will simulate impairment of several distinct thalamic regions through optogenetic inhibition to elucidate their roles in comparisons. Next, we will investigate how these dynamic interactions between the thalamic nuclei and cortical regions develop as animals begin to learn these tasks and as they acquire skilled performance. A key aspect of our design is that we will carefully monitor spontaneous motions and our analyses will control for activity in the thalamic nuclei related to these movements, which are often correlated with cognitive tasks, and would otherwise confound the analyses. This project will elucidate the roles of the different higher-order thalamic nuclei and of cortical feedback to these nuclei in gating cognitive processes across several sensory modalities. We expect these findings to yield many insights about thalamocortical network function during sensory processing, leading to greater understanding of cognitive function in the animal models used to study neurological and psychiatric disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $149,569 )
2026	2026	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 360	EAST LANSING	MI	48824	INGHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	7/27/2026	NON-COMPETING CONTINUATION	$149,569
														Subtotal = $149,569

Issue Date FY: 2025 ( Subtotal = $149,569 )
2025	2025	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	6/5/2025	NON-COMPETING CONTINUATION	$149,569
														Subtotal = $149,569

Issue Date FY: 2024 ( Subtotal = $145,082 )
2024	2024	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	8/22/2024	NON-COMPETING CONTINUATION	$10,470
2024	2024	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	6/17/2024	NON-COMPETING CONTINUATION	$134,612
														Subtotal = $145,082

Issue Date FY: 2023 ( Subtotal = $144,874 )
2023	2023	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	6/14/2023	NON-COMPETING CONTINUATION	$144,874
														Subtotal = $144,874

Issue Date FY: 2022 ( Subtotal = $152,374 )
2022	2022	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	6/30/2022	NEW	$152,374
														Subtotal = $152,374

Grand Total All Awards = $741,468

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CRCNS: Dynamics of thalamocortical networks during sensory discrimination

Award Number: R01NS130919

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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