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Area 3b hand cortex in primate: the targets and sources of extra-hand suppressive surrounds

Award Number: R01NS129982
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Summary Our previous studies have revealed a complex organization of receptive fields (RFs) of neurons in primary somatosensory cortex of monkeys (area 3b). The neurons have small excitatory centers that create the somatotopic map of the hand, a suppressive surround that includes all of the rest of the glabrous hand, and a weaker suppressive surround that includes all of the skin on the other hand (the “extra hand” surround). We propose to determine if neurons in different layers have similar or different surrounds, what surround features are relayed from the thalamus to area 3b neurons, and the connections that mediate different parts of the surround by inactivating cortical areas that directly or indirectly provide feedback to area 3b hand neurons. In addition, we will determine how a major loss of sensory inputs from the hand, due to selective spinal cord lesions, alters the center-surround relationships of neurons in the deprived and non-deprived 3b hand cortex, even after extensive post lesion recovery of 3b reactivation and hand use. The expected results will greatly expand our understanding of how tactile information from the hands is processed in the somatosensory system, and how processing is impaired and recovered following sensory loss. These results will have a clear impact on therapeutic intervention following spinal cord injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $332,084 )
2025	2025	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	12/13/2024	NON-COMPETING CONTINUATION	$332,084
														Subtotal = $332,084

Issue Date FY: 2024 ( Subtotal = $348,281 )
2024	2024	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/12/2023	NON-COMPETING CONTINUATION	$323,150
2024	2024	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	5/14/2024	NON-COMPETING CONTINUATION	$25,131
														Subtotal = $348,281

Issue Date FY: 2023 ( Subtotal = $386,720 )
2023	2023	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	12/21/2022	NEW	$386,720
														Subtotal = $386,720

Grand Total All Awards = $1,067,085

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Area 3b hand cortex in primate: the targets and sources of extra-hand suppressive surrounds

Award Number: R01NS129982

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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