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Defining the remote effects of cortical spreading depolarizations on hippocampus after traumatic brain injury

Award Number: R01NS129922
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Over 223,000 patients with traumatic brain injury (TBI) are hospitalized in the United States annually, with more than 166 deaths each day. It has been demonstrated over the past two decades of clinical research that cortical spreading depolarizations (CSDs), also known as “brain tsunamis,” are waves of electrical activity that occur in 60% of patients with TBI. CSDs are waves of massive neuronal depolarization that cause periods of electrical silencing and are independently associated with worse 6-month outcomes in TBI patients. It is unknown whether CSDs cause damage beyond the area of local cortical spread, and it is unknown how CSDs cause poor outcomes after TBI. We hypothesize that CSDs cause remote effects in hippocampus of TBI brain that contribute to poor outcomes. We will test this hypothesis in an experimental model of TBI and CSDs. We will define CSDs remote effects on electrophysiology, histopathology, and adult neurogenesis. Additionally, it will be tested whether CSDs cause remote effects via a trans-synaptic mechanism. Understanding the remote effects of CSDs will provide a paradigm shift in how we think about CSDs when they are observed clinically, and provide insight into TBI therapeutics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $575,746 )
2024	2024	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	4/25/2024	NON-COMPETING CONTINUATION	$41,549
2024	2024	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/18/2024	NON-COMPETING CONTINUATION	$534,197
														Subtotal = $575,746

Issue Date FY: 2023 ( Subtotal = $652,802 )
2023	2023	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/9/2023	NEW	$652,802
														Subtotal = $652,802

Grand Total All Awards = $1,228,548

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Defining the remote effects of cortical spreading depolarizations on hippocampus after traumatic brain injury

Award Number: R01NS129922

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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