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A longitudinal study of traumatic brain injury in a high-risk population

Award Number: R01NS126742
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/04/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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A longitudinal study of traumatic brain injury in a high-risk population - Project Summary/Abstract Traumatic brain injury (TBI) is a global concern that precipitates a diverse set of health consequences. TBI is a major concern in forensic populations -- an issue recently highlighted by calls for research by national public health institutions [1]. Indeed, upwards of 60% of inmates have a history of TBI, a rate seven times higher than the general population (8.5%) [2, 3]. TBI is a criminogenic risk factor [3, 4] and even mild TBI increases the rates of risk-taking behavior, substance use, and future offending [2, 4]. Over the last decade our team has been continuously funded by NIH to collect detailed clinical and neuroimaging protocols from over 4000 incarcerated men and women. We utilize a unique pair of twin mobile MRI units that are deployed directly on the secure grounds of forensic facilities, making it possible to conduct this research. Our dataset includes multimodal neuroimaging protocols, thorough clinical assessment, neuropsychological evaluations, and histories of TBI. All of our n>4000 offenders have consented to participate in longitudinal follow-up studies. For this project, we will commence a longitudinal study on n=300 individuals aged 35+, examining variables that will differentiate trajectories associated with cognitive impairments. We will also leverage advanced neuroimaging tools developed by our team to provide brain-based measures of cognitive decline and imaging-based classification tools for identifying brain injuries and comorbid conditions (i.e., substance abuse, psychopathy scores, depression, etc.). We will also examine how the brain injury profiles and comorbid conditions change over time. The availability of these unique resources to examine this highly underserved population makes this an exciting project with the potential to break new ground in our understanding of individual risk needs and divergent outcomes in TBI and neurodegenerative disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $670,150 )
2025	2025	LOVELACE BIOMEDICAL RESEARCH INSTITUTE	2425 RIDGECREST DR SE	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	6/13/2025	NON-COMPETING CONTINUATION	$670,150
														Subtotal = $670,150

Issue Date FY: 2024 ( Subtotal = $830,832 )
2024	2024	LOVELACE BIOMEDICAL RESEARCH INSTITUTE	2425 RIDGECREST DR SE	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	5/30/2024	NON-COMPETING CONTINUATION	$650,044
2024	2024	LOVELACE BIOMEDICAL RESEARCH INSTITUTE	2425 RIDGECREST DR SE	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	9/17/2024	SUPPLEMENT FOR EXPANSION	$180,788
														Subtotal = $830,832

Issue Date FY: 2023 ( Subtotal = $959,797 )
2023	2023	LOVELACE BIOMEDICAL RESEARCH INSTITUTE	2425 RIDGECREST DR SE	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	5/31/2023	NON-COMPETING CONTINUATION	$689,950
2023	2023	LOVELACE BIOMEDICAL RESEARCH INSTITUTE	2425 RIDGECREST DR SE	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	9/11/2023	SUPPLEMENT FOR EXPANSION	$269,847
2023	2022	LOVELACE BIOMEDICAL RESEARCH INSTITUTE	2425 RIDGECREST DR SE	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/3/2023	NEW	$0
														Subtotal = $959,797

Issue Date FY: 2022 ( Subtotal = $689,950 )
2022	2022	LOVELACE BIOMEDICAL RESEARCH INSTITUTE	2425 RIDGECREST DR SE	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/3/2022	NEW	$689,950
														Subtotal = $689,950

Grand Total All Awards = $3,150,729

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A longitudinal study of traumatic brain injury in a high-risk population

Award Number: R01NS126742

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/04/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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