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Neurogenesis in the adult Drosophila brain

Award Number: R01NS126444
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/15/2023
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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Neurogenesis in the adult Drosophila brain - Project Summary One of the barriers to therapeutic neural regeneration in humans is the absence of neural stem cells in most regions of the adult brain. Nonetheless, it would be advantageous to induce regeneration from resident cells. In addition, progress in the field would be accelerated if neural regeneration from resident cells could be investigated using a genetic model organism. Toward this end, we have developed a novel adult neurogenesis model in the Drosophila melanogaster central brain. We find that despite the absence of known neural progenitors, cells in the adult Drosophila central brain proliferate following injury, giving rise to both new neurons and new glial cells. Further, the new neurons project both axons and dendrites to specific target regions. We also observe functional recovery of behavioral deficits, suggesting that the new neurons integrate appropriately into neural circuits. Our results are paradigm-shifting because they suggest that resident brain cells can mediate neural regeneration. Here, we propose to utilize the model to investigate the signaling pathways and cellular mechanisms that regulate adult neurogenesis. Based on compelling preliminary data, our central hypothesis is that adult-born neurons are responsible for functional recovery from brain injury and that these neurons arise separately from adult-born glia. This hypothesis is supported by multiple lines of evidence from our ongoing work. We have identified, and are now investigating, genes uniquely upregulated during neural regeneration. The work proposed here will provide critical data about the molecular mechanisms that underlie that adult neurogenesis. Our work is innovative and has translational relevance because it shifts the focus of neural regeneration away from stem cell transplants and toward resident cell populations and it may lead to the identification of therapeutic targets for the stimulation of brain regeneration in humans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $388,752 )
2026	2026	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	3/19/2026	NON-COMPETING CONTINUATION	$38,875
2026	2026	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	1/22/2026	NON-COMPETING CONTINUATION	$349,877
														Subtotal = $388,752

Issue Date FY: 2025 ( Subtotal = $349,877 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	1/1/2025	NON-COMPETING CONTINUATION	$349,877
														Subtotal = $349,877

Issue Date FY: 2024 ( Subtotal = $377,089 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	5/3/2024	NON-COMPETING CONTINUATION	$27,212
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/12/2024	NON-COMPETING CONTINUATION	$349,877
														Subtotal = $377,089

Issue Date FY: 2023 ( Subtotal = $388,752 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/13/2023	NEW	$388,752
														Subtotal = $388,752

Grand Total All Awards = $1,504,470

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Neurogenesis in the adult Drosophila brain

Award Number: R01NS126444

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/15/2023

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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