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Optimizing Recovery prediction after Cardiac Arrest (ORCA)

Award Number: R01NS124642
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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Optimizing Recovery prediction after Cardiac Arrest (ORCA) - Abstract Predicting recovery from anoxic brain injury and coma after cardiac arrest is challenging. Although patients resuscitated from cardiac arrest are intensively monitored in critical care units, clinicians use only a tiny subset of available data to predict potential for recovery, making neurological prognostication both slow and imprecise. This is a specific example of a ubiquitous problem in modern medicine: routine clinical monitoring generates vast quantities of rich information, but tools to transform these data to useful knowledge are lacking. This project will leverage expertise in post-arrest critical care, information science, statistical modeling and machine learning to make a system that rapidly delivers actionable prognostic knowledge. We have cleaned, organized and aggregated a large, highly multivariate time series database with physiological and clinical information with over 170,000 hours of quantitative electroencephalographic (EEG) features for >1,850 post- arrest patients. We will refine and optimize analytical tools that predict recovery in this patient population more rapidly and accurately than clinical experts. We will use innovative approaches to minimize risk of bias during training of models introduced by outcome labels created by fallible human providers. In Aim 1 of this proposal, we will use novel approaches to create informative and interpretable features from heterogeneous clinical data including EEG waveforms, vital signs, medications and laboratory test results. We will use deep learning to identify interpretable and parsimonious sets of these features that predict outcome. We will train, test and compare the performance of multiple analytical tools. In Aim 2, we will prospectively compare the best performing model(s) against a panel of expert clinicians. Models that confidently identify patients with near-zero prospect of recovery with greater sensitivity or faster than expert clinicians can serve as decision support systems. Improving the speed and accuracy of post-arrest prognostication will save lives, allow appropriate resources to be directed to patients who are likely to benefit, avoid long and difficult care for patients who cannot recover, and spare families the agony of uncertainty.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $561,623 )
2026	2026	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	1/31/2026	NON-COMPETING CONTINUATION	$561,623
														Subtotal = $561,623

Issue Date FY: 2025 ( Subtotal = $646,981 )
2025	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	1/10/2025	NON-COMPETING CONTINUATION	$582,283
2025	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	8/5/2025	NON-COMPETING CONTINUATION	$64,698
														Subtotal = $646,981

Issue Date FY: 2024 ( Subtotal = $636,141 )
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	4/25/2024	NON-COMPETING CONTINUATION	$45,907
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	2/23/2024	NON-COMPETING CONTINUATION	$590,234
														Subtotal = $636,141

Issue Date FY: 2023 ( Subtotal = $630,640 )
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	2/3/2023	NON-COMPETING CONTINUATION	$630,640
														Subtotal = $630,640

Issue Date FY: 2022 ( Subtotal = $653,906 )
2022	2022	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/1/2022	NEW	$653,906
														Subtotal = $653,906

Grand Total All Awards = $3,129,291

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Optimizing Recovery prediction after Cardiac Arrest (ORCA)

Award Number: R01NS124642

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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