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Randomized Comparison of the Clinical Outcome of Single Versus Multiple Arterial Grafts: Cognition (ROMA:Cog)

Award Number: R01NS123639
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/18/2026
PERIOD OF PERFORMANCE END DATE: 11/30/2026

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Randomized Comparison of the Clinical Outcome of Single Versus Multiple Arterial Grafts: Cognition (ROMA:Cog) - PROJECT SUMMARY / ABSTRACT Postoperative neurocognitive disorders are common after coronary artery bypass grafting (CABG) and often present as executive dysfunction, threatening patient independence and driving healthcare utilization. Their biological mechanisms remain poorly understood, which limits early risk stratification and the development of preventive strategies. Emerging evidence points to a vascular-like cognitive phenotype after CABG—disproportionate impairment in executive function—linked to blood-brain barrier disruption and white matter injury. Neuroinflammation, including microglial response, is a leading candidate mechanism that may bridge these processes, yet no circulating marker of microglial response has been examined in CABG patients. The parent award (R01NS123639; ROMA:Cog) characterizes postoperative cognitive trajectories and MRI markers of brain injury and measures plasma biomarkers of neuronal injury, astrocytic activation, and tau-related pathology, but includes no marker of microglial response. This administrative supplement fills that gap. Our long-term objective is to improve mechanistic understanding and early risk stratification for cognitive decline after cardiac surgery by integrating biologically informative blood biomarkers with cognitive and neuroimaging outcomes. Using existing biospecimens, cognitive testing, and MRI data from the parent cohort, we will test whether plasma soluble TREM2 (sTREM2)—a marker of microglial response associated with early cognitive impairment in vascular-related phenotypes and with postoperative cognitive dysfunction in animal models—is associated with early postoperative executive dysfunction. Aim S1 will characterize plasma sTREM2 concentrations 6 weeks after CABG, including its distribution, outliers, and exploratory patterns by age, sex, and MRI-identified infarct status. Aim S2 will test whether higher 6-week sTREM2 is associated with worse 6-week domain-specific cognition—with executive function (Creyos Reasoning) as the focal domain. Stored plasma will be assayed for sTREM2 using validated Single-molecule-array (Simoa) immunoassays with standard quality control and blinding to cognitive outcomes. This time-sensitive analysis adds only the incremental cost of the assays, yielding effect-size estimates, variability parameters to power a future longitudinal study, and an open-access dataset. By leveraging existing cohort infrastructure, this supplement generates the first evidence in CABG patients linking a blood-based microglial response marker to early postoperative cognitive decline—directly advancing NIH priorities in brain health and neurological outcomes. Results will sharpen identification of at-risk patients and inform future mechanistic and biomarker-enabled strategies to prevent or mitigate postoperative neurocognitive disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $816,739 )
2026	2026	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	3/6/2026	SUPPLEMENT FOR EXPANSION	$33,923
2026	2026	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	2/27/2026	NON-COMPETING CONTINUATION	$732,816
2026	2026	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	5	9/1/2026	SUPPLEMENT FOR EXPANSION	$50,000
2026	2026	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	3/25/2026	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $816,739

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	4	9/22/2025	OTHER REVISION	$0
2025	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	4	9/22/2025	OTHER REVISION	$0
2025	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	3/13/2025	NON-COMPETING CONTINUATION	$0
2025	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	3/14/2025	TERMINATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $939,804 )
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	4	7/16/2024	NON-COMPETING CONTINUATION	$781,935
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	4	9/10/2024	SUPPLEMENT FOR EXPANSION	$157,869
2024	2022	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	6/11/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$466,301
2024	2021	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	6/11/2024	NEW	-$466,301
														Subtotal = $939,804

Issue Date FY: 2023 ( Subtotal = $859,754 )
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	7/14/2023	SUPPLEMENT FOR EXPANSION	$62,510
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	6/28/2023	NON-COMPETING CONTINUATION	$797,244
2023	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	11/22/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $859,754

Issue Date FY: 2022 ( Subtotal = $902,427 )
2022	2022	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/13/2022	SUPPLEMENT FOR EXPANSION	$19,916
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	9/13/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$839,917
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	2	9/19/2022	SUPPLEMENT FOR EXPANSION	$62,510
2022	2022	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	1	9/19/2022	SUPPLEMENT FOR EXPANSION	-$19,916
2022	2021	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	9/13/2022	NEW	$0
														Subtotal = $902,427

Issue Date FY: 2021 ( Subtotal = $835,104 )
2021	2021	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/6/2021	NEW	$835,104
														Subtotal = $835,104

Grand Total All Awards = $4,353,828

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Randomized Comparison of the Clinical Outcome of Single Versus Multiple Arterial Grafts: Cognition (ROMA:Cog)

Award Number: R01NS123639

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/18/2026

PERIOD OF PERFORMANCE END DATE: 11/30/2026

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