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Mechanisms of Timing and Temporal Coding

Award Number: R01NS122837
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2021
PERIOD OF PERFORMANCE END DATE: 11/30/2026

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Mechanisms of Timing and Temporal Coding - Project Summary/Abstract: One of the least understood computations in the brain is timing. We propose to combine large-scale simulations with eyelid conditioning experiments to reveal temporal coding mechanisms that underlie the cerebellum’s capacity for timing. The feasibility and power of this approach is facilitated by several related factors. Eyelid conditioning provides the ability to control cerebellar inputs and infer its output. Indeed, cerebellar timing is most clearly revealed in this way. This eyelid conditioning-cerebellum connection makes it possible to test large-scale cerebellar simulations in quantitative and biological relevant ways. There is also a natural synergy arising from combining simulations with experiments when each can be related with the other – simulation results suggest better experiments and interpretation of data, experiments inform simulations and make them more relevant and useful. The proposed studies are based on two relatively new discoveries about cerebellar connectivity: Golgi cells inhibit each other and deep cerebellar nucleus (DCN) neurons send collateral axons back to cerebellar cortex as mossy fibers. Preliminary data from simulations and experiments suggest these two connections confer the cerebellum with its capacity for timing and temporal coding. Simulations suggest specific predictions that can be tested with eyelid conditioning studies that include behavioral analysis, tetrode recordings and opto-genetic silencing of specific neurons. Results will inform more general theories of how neurons and synapses can implement temporal coding.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $350,307 )
2025	2025	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	11/21/2024	NON-COMPETING CONTINUATION	$350,307
														Subtotal = $350,307

Issue Date FY: 2024 ( Subtotal = $377,553 )
2024	2024	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	11/17/2023	NON-COMPETING CONTINUATION	$350,307
2024	2024	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	4/15/2024	NON-COMPETING CONTINUATION	$27,246
														Subtotal = $377,553

Issue Date FY: 2023 ( Subtotal = $389,230 )
2023	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	2/1/2023	NON-COMPETING CONTINUATION	$38,923
2023	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/7/2022	NON-COMPETING CONTINUATION	$350,307
														Subtotal = $389,230

Issue Date FY: 2022 ( Subtotal = $389,230 )
2022	2022	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	12/15/2021	NEW	$389,230
														Subtotal = $389,230

Grand Total All Awards = $1,506,320

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Mechanisms of Timing and Temporal Coding

Award Number: R01NS122837

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2021

PERIOD OF PERFORMANCE END DATE: 11/30/2026

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