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Combining Serotonergic Neural Progenitor Transplantation and Exercise to Improve Cardiac Disorders and Autonomic Dysreflexia After Spinal Cord Injury

Award Number: R01NS121336
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project summary Disruption of supraspinal regulation causes reduced sympathetic and unopposed parasympathetic activity, leading to cardiac and hemodynamic disorders after high-level spinal cord injury (SCI). We recently reported that renewal of serotonergic regulation over hemodynamics could be achieved with transplantation of embryonic raphe nucleus-derived neural progenitors/stem cells (RN-NPCs) in a rat SCI model. It was previously showed that exercise, a viable therapeutic intervention, heightens neuronal activity, axonal regrowth, and production of neurotrophic factors after SCI. Accordingly, we posit that transplanting serotonergic NPCs in the injured spinal cord will reestablish serotonin regulation to improve cardiac function, and combining RN-NPC grafts with exercise will enhance the recovery of cardiac activity, hemodynamics, and autonomic dysreflexia after SCI. In Aim 1, we will determine whether integration of transplanted serotonergic NPCs with spinal cord circuitry will restore sympathetic regulation to improve cardiac electrical conduction following SCI. In Aim 2, we will test whether combining RN-NPC transplants with exercise will further enhance the reconstitution of sympathetic modulation to restore cardiac activity, hemodynamics, and autonomic dysreflexia. Overall, this project will provide novel insight into therapeutic strategy following SCI.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $348,125 )
2025	2025	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	1/24/2025	NON-COMPETING CONTINUATION	$348,125
														Subtotal = $348,125

Issue Date FY: 2024 ( Subtotal = $365,115 )
2024	2024	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	4	9/9/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$365,114
2024	2024	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	4/24/2024	NON-COMPETING CONTINUATION	$26,348
2024	2024	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	2/22/2024	NON-COMPETING CONTINUATION	$338,767
2024	2024	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	9/9/2024	NON-COMPETING CONTINUATION	-$365,114
														Subtotal = $365,115

Issue Date FY: 2023 ( Subtotal = $368,959 )
2023	2023	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/31/2023	NON-COMPETING CONTINUATION	$368,959
														Subtotal = $368,959

Issue Date FY: 2022 ( Subtotal = $368,959 )
2022	2022	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/14/2022	NEW	$368,959
														Subtotal = $368,959

Grand Total All Awards = $1,451,158

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Combining Serotonergic Neural Progenitor Transplantation and Exercise to Improve Cardiac Disorders and Autonomic Dysreflexia After Spinal Cord Injury

Award Number: R01NS121336

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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