Monday, December 22, 2025 12/22/2025

Defining and exploiting the plasticity transcriptome to repair the damaged spinal cord

Award Number: R01NS121026
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2021
PERIOD OF PERFORMANCE END DATE: 11/30/2026

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Defining and exploiting the plasticity transcriptome to repair the damaged spinal cord - SUMMARY A century of research has shown that the adult central nervous system is incapable of self-repair after injury or disease. Indeed, adults with traumatic spinal cord injuries maintain chronic functional deficits that impact all aspects of their lives. However, increasing evidence suggests that the adult CNS retains some ability to initiate a growth program and functionally re-organize in response to activity, experience and mild trauma and particularly after intensive rehabilitative therapy. In this proposal we have used in vivo viral tracing in combination with FACS and single cell RNA sequencing to develop a comprehensive anatomical and molecular atlas of the adult corticospinal tract (CST). We plan to leverage this atlas to define the molecular mechanisms that drive axon growth in specific subsets of corticospinal tract neurons during rehab in the presence and absence of the axon growth inhibitors nogo receptor-1. We believe that a comprehensive understanding of the intrinsic molecular mechanism that initiates and sustains rehab-mediated axon growth within defined subsets of CST neurons can then be exploited to design novel therapies to repair the acutely and chronically damaged spinal cord.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $239,839 )
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/16/2025	NON-COMPETING CONTINUATION	$239,839
														Subtotal = $239,839

Issue Date FY: 2025 ( Subtotal = $474,340 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	11/20/2024	NON-COMPETING CONTINUATION	$239,840
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	9/10/2025	SUPPLEMENT FOR EXPANSION	$234,500
														Subtotal = $474,340

Issue Date FY: 2024 ( Subtotal = $450,740 )
2024	2024	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	12/18/2023	NON-COMPETING CONTINUATION	$418,215
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	5/10/2024	NON-COMPETING CONTINUATION	$32,525
														Subtotal = $450,740

Issue Date FY: 2023 ( Subtotal = $446,905 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	1/31/2023	NON-COMPETING CONTINUATION	$44,690
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/8/2022	NON-COMPETING CONTINUATION	$402,215
														Subtotal = $446,905

Issue Date FY: 2022 ( Subtotal = $457,771 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	12/8/2021	NEW	$457,771
														Subtotal = $457,771

Grand Total All Awards = $2,069,595

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Defining and exploiting the plasticity transcriptome to repair the damaged spinal cord

Award Number: R01NS121026

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2021

PERIOD OF PERFORMANCE END DATE: 11/30/2026

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