Sunday, July 6, 2025 7/6/2025

Inhibitory Neuron Sub-populations and Their Influence on Hemodynamic Imaging

Award Number: R01NS117515
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2021
PERIOD OF PERFORMANCE END DATE: 01/31/2026

Group Awards By:

View Award Description

Inhibitory Neuron Sub-populations and Their Influence on Hemodynamic Imaging - PROJECT SUMMARY/ABSTRACT Neuronal activity actively modulates local cerebral vasculature. This neuro-vascular interaction is the foundation of imaging studies of human brain function in health and disease. These studies are routinely performed while subjects perform tasks (evoked activity) or lie resting (task-free or resting-state activity), and they assume that imaging signals loyally reflect local neuronal activity. However, the neuro-vascular signaling mechanism is complex and instances of uncoupling have been reported, limiting the interpretability of these studies. Recent reports have shown that different types of neurons can regulate local blood supply stronger than others, especially inhibitory neurons. These findings underscore the need to understand the vaso-regulatory roles of different neuronal populations, especially considering that neurological disorders have been associated with dysfunction of specific inhibitory neuron sub-populations. The goal of this proposal is to determine the role of different sub-populations of inhibitory neurons on the regulation of local blood flow during evoked stimulation as well as during resting-state activity periods. Experiments will be performed using unique transgenic mouse models. In addition, we will determine whether these findings generalize over different cortical regions and explore the translatability of these findings to human subjects by comparing the distribution of inhibitory neurons that strongly regulate local blood flow in targeted regions of mouse and human brains. Our group has extensive multi-modal expertise in neuro-vascular (and neuro-metabolic) physiology, including the models and techniques proposed, and we are uniquely positioned to successfully complete the aims of this project. We will achieve these goals through three aims: (Aim 1) Determine which inhibitory neuron sub-types strongly regulate local blood flow changes evoked by optogenetic stimulation in different cortical regions; (Aim 2) Determine whether the same sub-population of inhibitory neurons regulate local blood flow changes during ongoing awake activity periods; and (Aim 3) Determine whether the sub-populations of inhibitory neurons identified in Aims 1 and 2 are similarly distributed across the targeted regions of mouse and human brains. Since inhibitory neurons shape network activity, these studies will detail the impact of specific inhibitory neuronal sub-type function and dysfunction on local blood supply and hemodynamic-based imaging signals, expanding the interpretability and clinical utility of human brain imaging studies in health and disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $454,266 )
2025	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	1/17/2025	NON-COMPETING CONTINUATION	$454,266
														Subtotal = $454,266

Issue Date FY: 2024 ( Subtotal = $515,456 )
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	1/18/2024	NON-COMPETING CONTINUATION	$478,260
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	4/24/2024	NON-COMPETING CONTINUATION	$37,196
														Subtotal = $515,456

Issue Date FY: 2023 ( Subtotal = $551,205 )
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	2/6/2023	NON-COMPETING CONTINUATION	$551,205
														Subtotal = $551,205

Issue Date FY: 2022 ( Subtotal = $547,639 )
2022	2022	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	4/6/2022	NON-COMPETING CONTINUATION	$54,764
2022	2022	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/21/2022	NON-COMPETING CONTINUATION	$492,875
														Subtotal = $547,639

Issue Date FY: 2021 ( Subtotal = $545,192 )
2021	2021	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/15/2021	NEW	$545,192
														Subtotal = $545,192

Grand Total All Awards = $2,613,758

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Inhibitory Neuron Sub-populations and Their Influence on Hemodynamic Imaging

Award Number: R01NS117515

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2021

PERIOD OF PERFORMANCE END DATE: 01/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer