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Indirect Spinal Ascending Pathways to Control Skilled Movements

Award Number: R01NS115963
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2031

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Indirect Spinal Ascending Pathways to Control Skilled Movements - Abstract (Summary): Motor behaviors need both motor command and sensory feedback via descending and ascending motor circuits, respectively. Although many studies including ours made significant progress of our understanding of cellular and molecular mechanisms underlying descending control of skilled movements, those underlying ascending motor control remains much less clear. In this proposal, we focus on spinal interneurons as ascending spinal neurons. The ascending circuits send both tactile and proprioceptive sensory information from hand and limb to the spinal cord, and then the brain. The dorsal column nucleus in the brainstem is the first integration point in supraspinal neuraxis to receive afferent input both from ipsilateral sensory neurons and from cervical spinal projection neurons (CSPNs). In this proposal, we will anatomically map connectivity of excitatory and inhibitory CSPNs (Aim 1), examine physiological connectivity and neural activity of CSPNs (Aim 2), and determine how different CSPNs control muscle activation to regulate skilled movements (Aim 3). The rationale for the proposed research is that a determination of how different ascending neurons control distinct behaviors will provide new opportunities for motor recovery after injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $445,863 )
2026	2026	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	1589 AMSTERDAM AVE	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	8/28/2026	COMPETING CONTINUATION	$445,863
														Subtotal = $445,863

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	7/1/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $546,632 )
2024	2024	THE WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	2/16/2024	NON-COMPETING CONTINUATION	$507,185
2024	2024	THE WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	4/8/2024	NON-COMPETING CONTINUATION	$39,447
														Subtotal = $546,632

Issue Date FY: 2023 ( Subtotal = $563,538 )
2023	2023	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	2/11/2023	NON-COMPETING CONTINUATION	$563,538
														Subtotal = $563,538

Issue Date FY: 2022 ( Subtotal = $604,855 )
2022	2022	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/3/2022	NON-COMPETING CONTINUATION	$544,366
2022	2022	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	3/24/2022	NON-COMPETING CONTINUATION	$60,489
														Subtotal = $604,855

Issue Date FY: 2021 ( Subtotal = $580,946 )
2021	2021	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	2/23/2021	NON-COMPETING CONTINUATION	$580,946
														Subtotal = $580,946

Issue Date FY: 2020 ( Subtotal = $601,721 )
2020	2020	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/24/2020	NEW	$601,721
														Subtotal = $601,721

Grand Total All Awards = $3,343,555

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Indirect Spinal Ascending Pathways to Control Skilled Movements

Award Number: R01NS115963

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2031

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