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Dissecting Spinal Interneuron Circuits to Control Skilled Movements

Award Number: R01NS115963
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2020
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Dissecting Spinal Interneuron Circuits to Control Skilled Movements - The highly orchestrated muscle activation sequences during motor behaviors are achieved directly through the fine-tuned firing of motor neurons in the ventral spinal cord. These motor neurons are mainly regulated by spinal interneurons present in all mammals, which are, in turn, connected to other spinal neurons as well as various types of descending neurons from the brain, such as corticospinal (CS), reticulospinal and rubrospinal neurons. Until recently, the identities and functioning of the interneuron subtypes and descending neurons participating in individual circuits had remained elusive. What remains lacking is knowledge of the arrangement and functional role of the spinal interneuron subtypes in individual circuits. There is, therefore, a critical need to determine the anatomical and functional connectivity of these spinal interneuron subtypes and how they regulate motor behaviors. Our overall objectives in this application are to (i) map anatomical and functional connectivity of different classes of spinal interneurons (Aims 1 & 2), and (ii) elucidate how those interneurons effect motor behaviors (Aim 3). Our central hypothesis is that each interneuron subtype will exhibit preferential connections with distinct descending neurons to control discrete forms of locomotor and skilled movements.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $546,632 )
2024	2024	THE WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	2/16/2024	NON-COMPETING CONTINUATION	$507,185
2024	2024	THE WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	4/8/2024	NON-COMPETING CONTINUATION	$39,447
														Subtotal = $546,632

Issue Date FY: 2023 ( Subtotal = $563,538 )
2023	2023	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	2/11/2023	NON-COMPETING CONTINUATION	$563,538
														Subtotal = $563,538

Issue Date FY: 2022 ( Subtotal = $604,855 )
2022	2022	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/3/2022	NON-COMPETING CONTINUATION	$544,366
2022	2022	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	3/24/2022	NON-COMPETING CONTINUATION	$60,489
														Subtotal = $604,855

Issue Date FY: 2021 ( Subtotal = $580,946 )
2021	2021	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	2/23/2021	NON-COMPETING CONTINUATION	$580,946
														Subtotal = $580,946

Issue Date FY: 2020 ( Subtotal = $601,721 )
2020	2020	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/24/2020	NEW	$601,721
														Subtotal = $601,721

Grand Total All Awards = $2,897,692

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Dissecting Spinal Interneuron Circuits to Control Skilled Movements

Award Number: R01NS115963

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2020

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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