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Comprehensive White-matter Microstructure-informed Analytical Methods to Elucidate Neurobiological Mechanisms of Sports-related Concussion (SRC)

Award Number: R01NS112303
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Abstract Sports-related concussion (SRC), while often regarded as the mildest form of traumatic brain injury (TBI), is nevertheless a significant public health issue. Based on the estimates by the Centers for Disease Control, 1.6 to 3.8 million SRCs occur annually among high school and collegiate athletes. Athletes sustaining acute concussion have a wide spectrum of clinical signs and symptoms including psychological distress, cognitive impairment, and somatic symptoms. In some cases, these symptoms persist, and people with mild TBI may be at higher risk for neurodegenerative diseases, future TBI, and, in cases of repetitive injuries, chronic traumatic encephalopathy. While standardized assessment tools are useful in the clinical management of acute concussion, the underlying pathophysiology of SRC and the time course of physiological recovery after injury remain unclear. There is an immediate need to address the heterogeneity in the long-term consequences of SRC to facilitate concussion management. The proposed research aims to understand why some concussed athletes have prolonged recovery time and, more importantly, how to detect such extreme cases. Diffuse axonal injury is generally believed to be the initial white matter neuropathology associated with mild TBI. Nevertheless, this microscopic injury is more difficult to detect in human mild TBI. Modern diffusion MRI techniques offer increased biological specificity for describing white-matter alterations. Therefore, the goal of the proposed research is to determine whether these novel axonal metrics: (1) provide indirect evidence of diffuse axonal injury in human SRC; (2) help to explain heterogeneity in individual recovery trajectories; and (3) inform our understanding of the relationship between axonal injury in SRC and clinical manifestations of SRC.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $371,864 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	3/23/2023	NON-COMPETING CONTINUATION	$371,864
														Subtotal = $371,864

Issue Date FY: 2022 ( Subtotal = $768,114 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	4/11/2022	NON-COMPETING CONTINUATION	$371,864
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	5/17/2022	SUPPLEMENT FOR EXPANSION	$396,250
														Subtotal = $768,114

Issue Date FY: 2021 ( Subtotal = $377,253 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/30/2021	NON-COMPETING CONTINUATION	$377,253
														Subtotal = $377,253

Issue Date FY: 2020 ( Subtotal = $380,222 )
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/6/2020	NEW	$380,222
														Subtotal = $380,222

Grand Total All Awards = $1,897,453

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Comprehensive White-matter Microstructure-informed Analytical Methods to Elucidate Neurobiological Mechanisms of Sports-related Concussion (SRC)

Award Number: R01NS112303

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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