Sunday, August 17, 2025 8/17/2025

Top-down mechanisms and modulation of flexible tactile discrimination

Award Number: R01NS112200
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/05/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2030

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Top-down mechanisms and modulation of flexible tactile discrimination - ABSTRACT In contrast to fixed stimulus-response associations, flexible behavior allows organisms to respond differently to the same stimuli depending on their current goals. Given a relatively stable structure of the brain, how can organisms implement different stimulus-response associations in a context-dependent, goal-directed manner? While previous work has investigated the roles of various brain regions in flexible switching behavior, we still lack fundamental understanding of how neural signals propagating within and between brain regions underlie this important cognitive function. Our proposal focuses on the interactions between three different brain regions in mediating rule switching: the locus coeruleus, the orbitofrontal cortex, and the somatosensory cortex. We test specific hypotheses regarding the contributions of each of these circuits by combining pathway-specific perturbations with cellular-resolution neurophysiological recordings in task-performing mice. Altogether, we will provide a unifying framework for how the locus coeruleus, orbitofrontal cortex, and somatosensory cortex coordinate to implement flexible goal-directed behavior.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $573,688 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	6	8/4/2025	COMPETING CONTINUATION	$573,688
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	8/4/2025	NON-COMPETING CONTINUATION	$0
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	2/14/2025	NON-COMPETING CONTINUATION	$0
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	5/2/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $573,688

Issue Date FY: 2023 ( Subtotal = $330,944 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/30/2023	NON-COMPETING CONTINUATION	$330,944
														Subtotal = $330,944

Issue Date FY: 2022 ( Subtotal = $331,308 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	900 UNIVERSITY AVE	RIVERSIDE	CA	92521	RIVERSIDE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	4/18/2022	NON-COMPETING CONTINUATION	$331,308
														Subtotal = $331,308

Issue Date FY: 2021 ( Subtotal = $331,655 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/15/2021	NON-COMPETING CONTINUATION	$331,655
														Subtotal = $331,655

Issue Date FY: 2020 ( Subtotal = $331,987 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/17/2020	NON-COMPETING CONTINUATION	$331,987
														Subtotal = $331,987

Issue Date FY: 2019 ( Subtotal = $332,303 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFFICE BLDG	RIVERSIDE	CA	92521	RIVERSIDE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/8/2019	NEW	$332,303
														Subtotal = $332,303

Grand Total All Awards = $2,231,885

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Top-down mechanisms and modulation of flexible tactile discrimination

Award Number: R01NS112200

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/05/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2030

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