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SCH: INT: Collaborative Research: Multimodal Signal Analysis and Data Fusion for Post-traumatic Epilepsy

Award Number: R01NS111744
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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The research objective of this proposal, Multimodal Signal Analysis and Data Fusion for Post-traumatic Epilepsy Prediction, with Pl Dominique Duncan from the University of Southern California, is to predict the onset of epileptic seizures following traumatic brain injury (TBI), using innovative analytic tools from machine learning and applied mathematics to identify features of epileptiform activity, from a multimodal dataset collected from both an animal model and human patients. The proposed research will accelerate the discovery of salient and robust features of epileptogenesis following TBI from a rich dataset, collected from the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx), as it is being acquired by investigating state-of-the-art models, methods, and algorithms from contemporary machine learning theory. This secondary use of data to support automated discovery of reliable knowledge from aggregated records of animal model and human patient data will lead to innovative models to predict post-traumatic epilepsy (PTE). This machine learning based investigation of a rich dataset complements ongoing data acquisition and classical biostatistics-based analyses ongoing in the study and can lead to rigorous outcomes for the development of antiepileptogenic therapies, which can prevent this disease. Identifying salient features in time series and images to help design a predictor of PTE using data from two species and multiple individuals with heterogeneous TBI conditions presents significant theoretical challenges that need to be tackled. In this project, it is proposed to adopt transfer learning and domain adaptation perspectives to accomplish these goals in multimodal biomedical datasets across two populations. Specifically, techniques emerging from d,eep learning literature will be exploited to augment data, share parameters across model components to reduce the number of parameters that need to be optimized, and use state-of-the-art architectures to develop models for feature extraction. These will be compared against established pipelines of hand-crafted feature extraction in rigorous cross-validation analyses. Developed techniques for transfer learning will be able to extract features that generalize across animal and human data. Moreover, these theoretical techniques with associated models and optimization methods will be applicable to other multi-species transfer learning challenges that may arise in the context of health and medicine. Multimodal feature extraction and discriminative model learning for disease onset prediction using novel classifiers also offer insights into biomarker discovery using advanced machine learning techniques through joint multimodal data analysis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $241,476 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	5/16/2022	NON-COMPETING CONTINUATION	$241,476
														Subtotal = $241,476

Issue Date FY: 2021 ( Subtotal = $243,545 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	1/29/2021	NON-COMPETING CONTINUATION	$243,545
														Subtotal = $243,545

Issue Date FY: 2020 ( Subtotal = $245,552 )
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/31/2020	NON-COMPETING CONTINUATION	$245,552
														Subtotal = $245,552

Issue Date FY: 2019 ( Subtotal = $250,346 )
2019	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/25/2019	NEW	$250,346
														Subtotal = $250,346

Grand Total All Awards = $980,919

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SCH: INT: Collaborative Research: Multimodal Signal Analysis and Data Fusion for Post-traumatic Epilepsy

Award Number: R01NS111744

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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