Sunday, July 6, 2025 7/6/2025

Transduction of Mechanical Stimuli in Myelination and Peripheral Nerve Repair

Award Number: R01NS110627
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/15/2020
PERIOD OF PERFORMANCE END DATE: 12/31/2024

Group Awards By:

View Award Description

Transduction of Mechanical Stimuli in Myelination and Peripheral Nerve Repair - Mechanobiology is an emerging field which studies how physical forces and changes can contribute to cell differentiation, tissue formation and diseases. These forces are applied on cells through the local variations between neighbouring cells and the extracellular matrix. Notably, cell—cell and cell-extracellular matrix mechanical stimuli can stimulate electrochemical responses, the rearrangement of cytoskeletal structures and the regulation of gene expression. Schwann cells, the myelinating cells of the peripheral nervous system, are required for the function and health of the peripheral nervous system. Schwann cells also have a critical role in the regenerative potential of the peripheral nervous system, but very little is known about how Schwann cells sense axonal injury. We demonstrated that Schwann cells are exquisitely sensitive to alterations in the elasticity of the extracellular matrix; and that Schwann cell differentiation and myelination during the peripheral nervous system development depend on the transduction of mechanical stimuli by YAP and TAZ. Yet, it is unknown what are the signalling upstream and downstream YAP and TAZ in Schwann cells and if YAP and TAZ are also required for Schwann cell differentiation and remyelination after peripheral nerve injury. Here we will investigate if the transduction of mechanical stimuli in Schwann cells is critical to stimulate myelination and improve peripheral nerve regeneration. Our objectives are to determine if it is possible to manipulate Schwann cells mechanically to improve myelination, with therapeutic implications (Aim 3) and to discover new components of the mechanotransduction pathways upstream (Aim1) and downstream (Aim 2) of YAP and TAZ. Studying myelination through the mechanotransducers YAP and TAZ has potential to advance the field by identifying the therapeutic importance of Schwann cell and cellular mechanobiology and may reveal novel targets or mechanisms for myelin formation and peripheral nerve regeneration in neuropathies molecular.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $425,178 )
2024	2024	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/19/2023	NON-COMPETING CONTINUATION	$344,598
2024	2024	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	12/27/2023	SUPPLEMENT FOR EXPANSION	$53,777
2024	2024	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE # A34	ALBANY	NY	12208	ALBANY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	4/10/2024	NON-COMPETING CONTINUATION	$26,803
														Subtotal = $425,178

Issue Date FY: 2023 ( Subtotal = $440,303 )
2023	2023	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	12/20/2022	NON-COMPETING CONTINUATION	$347,873
2023	2023	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	4	1/30/2023	NON-COMPETING CONTINUATION	$38,653
2023	2023	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	12/30/2022	SUPPLEMENT FOR EXPANSION	$53,777
														Subtotal = $440,303

Issue Date FY: 2022 ( Subtotal = $420,818 )
2022	2022	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	11/23/2021	NON-COMPETING CONTINUATION	$348,057
2022	2022	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	5/23/2022	SUPPLEMENT FOR EXPANSION	$34,087
2022	2022	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	5/9/2022	NON-COMPETING CONTINUATION	$38,674
														Subtotal = $420,818

Issue Date FY: 2021 ( Subtotal = $386,625 )
2021	2021	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	1/26/2021	NON-COMPETING CONTINUATION	$38,664
2021	2021	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/14/2020	NON-COMPETING CONTINUATION	$347,961
														Subtotal = $386,625

Issue Date FY: 2020 ( Subtotal = $385,335 )
2020	2020	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/13/2020	NEW	$385,335
														Subtotal = $385,335

Grand Total All Awards = $2,058,259

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Transduction of Mechanical Stimuli in Myelination and Peripheral Nerve Repair

Award Number: R01NS110627

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/15/2020

PERIOD OF PERFORMANCE END DATE: 12/31/2024

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer